In the practiced condition, 23 brain parcels showed genotype differences in exponential model fit, mostly favoring the Met group and concentrated in frontal and striatal regions¶

Claim · All claims
Evidence · 1 study · associational r2 · q2
Currency · newest study 2024 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? 23 of 246 parcels showed a significant goodness-of-fit difference between genotype groups, with 17 showing better fit in the Met group, mainly frontal (8) and striatal (8) parcels. → Lena S. Geiger 2024

Evidence¶

Lena S. Geiger 2024¶

Lena S. Geiger, Torsten Wüstenberg, Zhenxiang Zang, Mirjam Melzer, Stephanie H. Witt, Marcella Rietschel, Markus M. Nöthen, Stefan Herms, Franziska Degenhardt, Andreas Meyer-Lindenberg & Carolin Moessnang. (2024). Longitudinal markers of cognitive procedural learning in fronto-striatal circuits and putative effects of a BDNF plasticity-related variant. npj Science of Learning. https://doi.org/10.1038/s41539-024-00282-2

q2 · i? · associational · r2

Likelihood-ratio comparison of exponential decay-curve fits between genotype groups across 246 parcels, Bonferroni corrected for 246 comparisons. The quote states "23 regions (~9% of the total amount of parcels) showed a significant difference in the GoF between genotype groups".

"Overall, 23 regions (~9% of the total amount of parcels) showed a significant difference in the GoF between genotype groups (see Table 3; see Supplementary Table 5 for a full report including all parcels)."

Discussion¶

Related Claims¶

• Repeated procedural training produces exponential decay of brain activation in a distributed set of regions including fronto-striatal circuits, paralleling exponential improvement in task performance — related
• Behavioral learning curves in a procedural working memory task are better fit by an exponential model than a linear model across five training sessions — related
• BDNF Val66Met genotype is associated with behavioral learning curves: Met-allele carriers show higher learning gain and, per the authors, less efficient early learning — related
• Subcortical but not cortical activation-trajectory parameters classify BDNF genotype above chance in an exploratory decision-tree analysis — related