Education-associated CpGs show dynamic methylation across foetal brain development (18 sites) and blood–brain methylation correlations (10 sites)¶

Claim · All claims
Evidence · 1 study · associational r3 · q2
Currency · newest study 2018 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? At 18 of the 58 top CpGs (31%), brain methylation changes as a function of foetal age (r = −0.57 to 0.38); at 10 CpGs (17%), blood methylation correlates with methylation in at least one of four brain regions (r = 0.36 to 0.63). → Jenny van Dongen et al 2018

Evidence¶

Jenny van Dongen et al 2018¶

Jenny van Dongen et al. (2018). DNA methylation signatures of educational attainment. npj Science of Learning 3:7. https://doi.org/10.1038/s41539-018-0020-2

q2 · i? · associational · r3

Look-up of the 58 top CpGs in two previously published Illumina 450k datasets of foetal brain development and matched post-mortem blood/brain samples. At 18 CpGs (31%) methylation changes as a function of foetal age (r = −0.57 to 0.38, p < 7.7 × 10−4); the strongest blood–brain correlation was cg05951221 (ALPPL2, r = 0.63 with superior temporal gyrus).

"At 10 of our top CpGs (17%), methylation level in blood correlates significantly with DNA methylation level in at least one out of four assessed brain regions, with correlations ranging from r = 0.36 to r = 0.63"

Discussion¶

Related Claims¶

• A meta-analysis of four Dutch cohorts identifies 58 CpG sites whose blood DNA methylation is associated with educational attainment, mostly with higher methylation at higher education — related