Methylation at 33 of 58 education-associated CpGs (57%) is associated with expression of nearby transcripts in blood¶

Claim · All claims
Evidence · 1 study · associational r3 · q2
Currency · newest study 2018 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? In 3002 whole-blood samples, methylation at 33 CpGs (57%) was associated with levels of one or more cis transcripts (P < 1.1 × 10−4, Bonferroni for 463 tests; 58 significant associations total). → Jenny van Dongen et al 2018

Evidence¶

Jenny van Dongen et al 2018¶

Jenny van Dongen et al. (2018). DNA methylation signatures of educational attainment. npj Science of Learning 3:7. https://doi.org/10.1038/s41539-018-0020-2

q2 · i? · associational · r3

Cis ( < 100 kb) methylation–expression analysis using 3002 whole-blood samples from the BIOS consortium with matched DNA methylation and RNA-seq. Confirmed methylation–expression relationships for AHRR, RARA, GPR15, MYO1G, ANPEP, ATP9A and SOCS3; cg05575921 and AHRR transcript level correlated negatively (beta = −4.5, p = 1.03 × 10−81).

"At 33 CpGs (57%), methylation level was associated (P < 1.1 × 10−4, Bonferroni correction for 463 tests) with the levels of one or multiple transcripts"

Discussion¶

Related Claims¶

• A meta-analysis of four Dutch cohorts identifies 58 CpG sites whose blood DNA methylation is associated with educational attainment, mostly with higher methylation at higher education — related
• Educational-attainment methylation sites overlap strongly with cigarette-smoke signatures, and associations remain after adjusting for smoking at 11 genome-wide significant CpGs — related