Freezing levels are negatively correlated with active avoidance performance across mice in the platform-based active avoidance paradigm¶

Claim · All claims
Evidence · 1 study · causal r1 · q3 · i3 large
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i3 Across mice in the shock-intensity validation experiment, freezing levels were negatively correlated with avoidance performance (Pearson r = −0.74). → Hanny Hayeon Lee 2026

Evidence¶

Hanny Hayeon Lee 2026¶

Hanny Hayeon Lee, Eul Han & Yong Sang Jo. (2026). CGRP inhibition in the PBN shifts defensive strategy from freezing to active avoidance in a platform-based active avoidance paradigm. npj Science of Learning. https://doi.org/10.1038/s41539-026-00453-3

q3 · i3 · causal · r1

Secondary correlational analysis across mice in the footshock-intensity validation experiment of the PBA paradigm: freezing levels were "nega- tively correlated with avoidance pe rformance across mice", Pearson r = −0.74, 95% CI [ −0.90, −0.42], p < 0.001.

"freezing levels were nega- tively correlated with avoidance pe rformance across mice (Pearson r = −0.74, 95% CI [ −0.90, −0.42], p < 0.001)."

Discussion¶

Related Claims¶

• Silencing CGRP neurons in the parabrachial nucleus does not impair active avoidance learning and expands successful avoidance to high footshock intensities — related
• CGRP silencing reduces freezing at high footshock intensities where control mice show significant increases in freezing — related
• In the platform-based active avoidance paradigm, 0.3 mA footshock optimally supports cue-evoked active avoidance, with lower intensities yielding weak avoidance and higher intensities promoting freezing that suppresses action — related
• Low footshock intensities (0.1-0.2 mA) yield weak avoidance learning in both CGRP-silenced and control mice — related