Evidence challenges protein-synthesis sufficiency for memory: memory formation is reported in a variety of tasks even during more than 90% reduction of protein¶

Claim · All claims
Evidence · 1 study (2 entries) · review r2 · q2
Currency · newest study 2016 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? The review lists demonstrations of memory formation in a variety of tasks even during more than 90% reduction of protein as evidence questioning the protein-centric view. → Paul Marshall and Timothy W Bredy 2016 q2 i? The review also cites Gisquet-Verrier and colleagues' finding that protein-synthesis-inhibitor impairment can be reversed when inhibitors are delivered both post-training and pre-test. → Paul Marshall and Timothy W Bredy 2016 (2)

Evidence¶

Paul Marshall and Timothy W Bredy 2016¶

Paul Marshall and Timothy W Bredy. (2016). Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory? npj Science of Learning. https://doi.org/10.1038/npjscilearn.2016.14

q2 · i? · review · r2

Narrative review listing four lines of evidence questioning the protein-synthesis perspective, including "the demonstration of memory formation in a variety of tasks even during more than 90% reduction of protein". It attributes this to multiple cited studies; no effect sizes are printed.

"the demonstration of memory formation in a variety of tasks even during more than 90% reduction of protein;"

Paul Marshall and Timothy W Bredy 2016 (2)¶

Paul Marshall and Timothy W Bredy. (2016). Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory? npj Science of Learning. https://doi.org/10.1038/npjscilearn.2016.14

q2 · i? · review · r2

In its integration section the review reports that "impairment by protein-synthesis inhibitors can be reversed if they are delivered both post-training and pre-test", citing Gisquet-Verrier and colleagues, raising the question of whether the epigenetic state of DNA, RNA and protein was changed.

"Gisquet-verrier et al. 103 have shown that impairment by protein-synthesis inhibitors can be reversed if they are delivered both post-training and pre-test."

Discussion¶

Related Claims¶

• Memories can persist and be reinstated in the absence of learning-induced synaptic alterations, supporting cell-intrinsic storage — related