Low footshock intensities (0.1-0.2 mA) yield weak avoidance learning in both CGRP-silenced and control mice¶

Claim · All claims
Evidence · 1 study · causal r1 · q3
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i? At 0.1-0.2 mA, neither TetTox nor control mice consistently reached the 5 s avoidance criterion across retention sessions, indicating weak avoidance learning irrespective of group; equivalence was not tested. → Hanny Hayeon Lee 2026

Evidence¶

Hanny Hayeon Lee 2026¶

Hanny Hayeon Lee, Eul Han & Yong Sang Jo. (2026). CGRP inhibition in the PBN shifts defensive strategy from freezing to active avoidance in a platform-based active avoidance paradigm. npj Science of Learning. https://doi.org/10.1038/s41539-026-00453-3

q3 · i? · causal · r1

Retention-test latency analysis at the low intensities of the CGRP-silencing experiment (n = 7 per group per intensity): neither group consistently reached the 5 s criterion, with "generally weak avoidance learning irrespective of any group differences".

"At lower shock intensities (0.1-0.2 mA), neither control nor TetTox mice consistently r eached this behavioural criterion across retention sessions, indicati ng generally weak avoidance learning irrespective of any group differences"

Discussion¶

Related Claims¶

• Silencing CGRP neurons in the parabrachial nucleus does not impair active avoidance learning and expands successful avoidance to high footshock intensities — related
• Freezing levels are negatively correlated with active avoidance performance across mice in the platform-based active avoidance paradigm — related
• In the platform-based active avoidance paradigm, 0.3 mA footshock optimally supports cue-evoked active avoidance, with lower intensities yielding weak avoidance and higher intensities promoting freezing that suppresses action — related
• CGRP silencing reduces freezing at high footshock intensities where control mice show significant increases in freezing — related