ADHD adults show lower D2/D3 receptor and DAT availability in nucleus accumbens and midbrain than controls¶

Claim · All claims
Evidence · 1 study · associational r2 · q3
Currency · newest study 2011 · not yet checked against its sources · not reviewed by a person · overdue for a recheck since 2016: baselines and conditions change

Subclaims¶

q3 i? Compared to controls, ADHD participants had significantly lower D2/D3 receptor and DAT availability in NAcc and midbrain regions. → Volkow ND 2011

Evidence¶

Volkow ND 2011¶

Volkow ND, Wang GJ, Newcorn JH, Kollins SH, Wigal TL, Telang F, Fowler JS, Goldstein RZ, Klein N, Logan J, Wong C, Swanson JM. (2011). Motivation Deficit in ADHD is Associated with Dysfunction of the Dopamine Reward Pathway. Molecular Psychiatry 16(11). https://doi.org/10.1038/mp.2010.97

q3 · i? · associational · r2

Group comparison of PET measures (Bmax/Kd ratios) in the same 45 ADHD vs 41 control cohort; Table 3 prints means (e.g., NAcc D2/D3 2.53±0.22 vs 2.65±0.27) with footnote significance levels of p<0.05 and p<0.01. No standardised effect size printed.

"Compared to controls, the ADHD participants had significantly lower measures of D2/D3 receptor and of DAT availability in NAcc and midbrain regions (averaged for left and right regions) (see Table 3)."

Discussion¶

Related Claims¶

• In adults with ADHD, dopamine D2/D3 receptor and DAT availability in the reward pathway correlate positively with trait motivation — related
• Positive Emotionality correlates with midbrain D2/D3 receptor availability in ADHD adults, while Negative Emotionality and Constraint do not — related
• Adults with ADHD score lower on the MPQ Achievement scale, a surrogate trait measure of motivation, than controls — related
• Lower trait motivation scores in ADHD adults are associated with more severe inattention symptoms, but not hyperactivity — related