Positive Emotionality correlates with midbrain D2/D3 receptor availability in ADHD adults, while Negative Emotionality and Constraint do not¶

Claim · All claims
Evidence · 1 study · associational r2 · q3 · i3 large
Currency · newest study 2011 · not yet checked against its sources · not reviewed by a person · overdue for a recheck since 2016: baselines and conditions change

Subclaims¶

q3 i3 In ADHD participants, Positive Emotionality correlated significantly with midbrain D2/D3 receptor availability (r=0.41, p<0.005), but correlations with Negative Emotionality and Constraint were not significant. → Volkow ND 2011

Evidence¶

Volkow ND 2011¶

Volkow ND, Wang GJ, Newcorn JH, Kollins SH, Wigal TL, Telang F, Fowler JS, Goldstein RZ, Klein N, Logan J, Wong C, Swanson JM. (2011). Motivation Deficit in ADHD is Associated with Dysfunction of the Dopamine Reward Pathway. Molecular Psychiatry 16(11). https://doi.org/10.1038/mp.2010.97

q3 · i3 · associational · r2

Secondary Pearson correlation analysis of MPQ broad factors against PET DA measures; midbrain D2/D3 with Positive Emotionality reached "r=0.41, p<0.005" in ADHD only. The authors attribute this to the Achievement scale being part of the Positive Emotionality factor.

"separate group analysis showed that this correlation was significant in ADHD participants (r=0.41, p<0.005) but not in controls. The correlations with Negative Emotionality and Constraint factors were not significant."

Discussion¶

Related Claims¶

• ADHD adults show lower D2/D3 receptor and DAT availability in nucleus accumbens and midbrain than controls — related
• Lower trait motivation scores in ADHD adults are associated with more severe inattention symptoms, but not hyperactivity — related
• In adults with ADHD, dopamine D2/D3 receptor and DAT availability in the reward pathway correlate positively with trait motivation — related
• Adults with ADHD score lower on the MPQ Achievement scale, a surrogate trait measure of motivation, than controls — related