Adults show significantly greater whole-brain fMRI activation than children for reversed versus typical letters, including left ventral visual stream and bilateral parietal cortices¶
Claim · All claims
Evidence · 1 study · causalr1·q3
Currency · newest study 2014 · not yet checked against its sources · not reviewed by a person · overdue for a recheck since 2019: baselines and conditions change
Subclaims¶
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q3 i? In a direct whole-brain comparison, adults exhibited significantly greater activation than children for the reversed > typical letters contrast in multiple regions including the left ventral visual stream and bilateral parietal cortices. → Blackburne LK 2014
Evidence¶
Blackburne LK 2014¶
Blackburne LK, Eddy MD, Kalra P, Yee D, Sinha P, Gabrieli JDE. (2014) Neural Correlates of Letter Reversal in Children and Adults. PLoS ONE 9(5): e98386. https://doi.org/10.1371/journal.pone.0098386
q3 · i? · causal · r1
Whole-brain random-effects fMRI analysis of the letter reversal task in 15 children (mean age 9.5) and 15 adults (mean age 22.3), thresholded at voxel-wise p <.01 with FDR cluster correction p <.05, with motion and artifact covariates. The direct group comparison showed "adults exhibited significantly greater activation" for reversed letters; children did not exhibit greater activation than adults in this contrast. No effect size was printed.
"Direct comparison of children and adults showed that adults exhibited significantly greater activation for the reversed . typical letters contrast than children did in multiple regions, including the left ventral visual stream and bilateral parietal cortices (Figure 3)."
Discussion¶
Related Claims¶
- Children show greater activation for typical than reversed letters in left inferior parietal lobule, left superior temporal gyrus, and early visual regions — the opposite of the adult pattern — related
- The N170 reversed-minus-typical amplitude difference correlates with the VWFA reversed-minus-typical activation difference across participants, but not within either group — related
- Adults, but not children, show a differential N170 response to typical versus reversed letters — related
- Math achievement correlates with ventral occipital-temporal NRE in both children and adults, with children relying on extrastriate and adults on anterior higher-order visual regions — related
Page metadata
| Field | Value |
|---|---|
type |
claim |
id |
adults-greater-fmri-activation-reversed-letters-than-children |
title |
Adults show significantly greater whole-brain fMRI activation than children for reversed versus typical letters, including left ventral visual stream and bilateral parietal cortices |
description |
Adults show significantly greater whole-brain fMRI activation than children for reversed versus typical letters, including left ventral visual stream and bilateral parietal cortices |
status |
review |
evidence_strength |
moderate |
newest_evidence |
2014 |
recheck_by |
2019 |
generated |
by process:wiki-ingest on 2026-10-17 |
trust |
unverified — no one has confirmed this page's content |
sources |
1 — blackburne-lk-2014 |
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