Children's own polygenic index for educational attainment is negatively associated with their depressive traits at age 8¶

Claim · All claims
Evidence · 1 study · causal r2 · q2 · i0 negligible
Currency · newest study 2024 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i0 A one-S.D. change in the child's education PGI corresponded to a 0.04 S.D. decrease in depressive traits. → Hughes 2024

Evidence¶

Hughes 2024¶

Hughes, A. M., Torvik, F. A., van Bergen, E., Hannigan, L. J., Corfield, E. C., Andreassen, O. A., Ystrom, E., Ask, H., Davey Smith, G., Davies, N. M. & Havdahl, A. (2024). Parental education and children’s depression, anxiety, and ADHD traits, a within-family study in MoBa. npj Science of Learning. https://doi.org/10.1038/s41539-024-00260-8

q2 · i0 · causal · r2

Within-family MR in MoBa trios adjusting for parental PGIs. The child's education PGI negatively associated with depressive traits: "a decrease of 0.04 S.D." per PGI S.D. (p = 0.001), about 0.1 point on the 26-point Short Mood and Feelings Questionnaire. The authors describe the effect as small.

"Theeffect was small: a one-S.D. change in the PGI corresponded to a decrease of 0.04 S.D. (CI = 0.02,−0.02,p = 0.001) in depressive traits, or around 0.1 point on a 26-point scale (Fig.3)."

Discussion¶

Related Claims¶

• Children's own polygenic index for educational attainment is negatively associated with their ADHD traits at age 8, independent of parental PGIs — related
• Within-family Mendelian randomization finds little evidence that mothers' or fathers' educational attainment causally affects children's depressive, anxiety, or ADHD traits at age 8 — related
• In complete-case sensitivity analyses, maternal education showed unexpected positive associations with children's depressive and ADHD-inattention traits — related
• Non-genetic models show small negative associations between parents' years of education and children's depressive traits, which attenuate once confounders are accounted for — related
• Two-sample MR finds inverse-variance weighted estimates linking maternal education to fewer depressive but more ADHD-inattention traits, with other estimators consistent with the null — related