Closed-loop auditory stimulation of slow oscillations and spindles evokes significant neurophysiological responses compared to sham in healthy young adults.¶
Claim · All claims
Evidence · 1 study · causalr2·q3
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person
Subclaims¶
Reading the evidence codes
q is the design tier, i the impact, n the sample, and the kind with its r
the rigour judged within that kind: what each code means.
This claim: no standardized effect is recorded in observations/ for it yet, so no benchmark reading is possible.
q3 i? Auditory stimulation delivered during SO up-states, at spindle onset, or 450 ms after spindle detection each evoked statistically significant changes in evoked slow wave and spindle band activity relative to sham. → Jourde 2026
Evidence¶
Jourde 2026¶
Jourde, H.R., Sita, K.Z., Eyqvelle, Z., Brooks, M., & Coffey, E.B.J. (2026). Modulating sleep: slow oscillation and spindle stimulation effects on physiology and memory. npj Science of Learning. https://doi.org/10.1038/s41539-025-00383-6
q3 · i? · causal · r2
In a randomized between-subjects nap study with 102 healthy young adults, stimulation during SO up-states produced a clear evoked slow oscillation with "statistically-significant differences from sham" between 0.5 and 1.5 seconds post stimulation, replicating prior CLAS findings.
"A clearevokedslowoscillationwasobservedwhensoundwas delivered during SO-up-states, with statistically-significant differences from sham (‘Sleep’ condition) between 0.5 and 1.5 seconds post stimulation"
Discussion¶
Related Claims¶
- Detected slow oscillation amplitude predicts evoked SO amplitude, and detected spindle amplitude predicts evoked spindle amplitude in delayed stimulation, but not cross-band. — related
- Evoked spindle activity showed modest negative correlations with piano task performance changes, while evoked SO strength showed no clear relationship with performance change. — related
- Immediate spindle stimulation truncates the stimulated spindle, while delayed stimulation enhances spindle activity without interruption. — related
- Slow oscillation and spindle stimulation did not differentially affect motor sequence learning improvement compared to control conditions. — related
- Auditory cueing during NREM sleep elevates slow wave and spindle power relative to no stimulation, with effects concentrated in frontal and central regions — a narrower finding that bears on this claim
- Cortical delta oscillations during slow-wave sleep support declarative memory consolidation — related
Page metadata
| Field | Value |
|---|---|
type |
claim |
id |
clas-evokes-significant-neurophysiological-responses |
title |
Closed-loop auditory stimulation of slow oscillations and spindles evokes significant neurophysiological responses compared to sham in healthy young adults. |
description |
Closed-loop auditory stimulation of slow oscillations and spindles evokes significant neurophysiological responses compared to sham in healthy young adults. |
status |
review |
evidence_strength |
moderate |
newest_evidence |
2026 |
generated |
by process:wiki-ingest on 2026-10-26 |
trust |
unverified — no one has confirmed this page's content |
sources |
1 — jourde-2026 |
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