Adults with dyscalculia show less distinct non-symbolic number representations than matched controls in anterior parietal, frontal and temporal cortex¶

Claim · All claims
Evidence · 1 study (2 entries) · associational r2 · q3
Currency · newest study 2019 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i? Searchlight MVPA shows significantly less distinct non-symbolic number representations in anterior parietal, frontal and temporal lobes in adults with dyscalculia compared to controls. → Bulthé Jessica 2019 q3 i? ROI-based decoding confirms less distinguishable non-symbolic representations in dyscalculia in All Regions, parietal lobe including IPS and right anterior IPS, temporal lobe and frontal lobe. → Bulthé Jessica 2019 (2)

Evidence¶

Bulthé Jessica 2019¶

Bulthé Jessica, Prinsen Jellina, Vanderauwera Jolijn, Duyck Stefanie, Daniels Nicky, Gillebert Céline R., Mantini Dante, Op de Beeck Hans P., De Smedt Bert. (2019). Multi-method brain imaging reveals impaired representations of number as well as altered connectivity in adults with dyscalculia. Neuroimage, 190, 289-302. https://doi.org/10.1016/j.neuroimage.2018.06.012

q3 · i? · associational · r2

Whole-brain MVPA searchlight analysis of fMRI data from 24 adults with dyscalculia and 24 matched controls during number comparison. The group comparison showed "significantly less distinct non-symbolic number representations" in dyscalculia in anterior parietal, frontal and temporal regions (FWE-corrected p < 0.05).

"A group comparison for non-symbolic numbers (Fig. 3C–D) clearly demonstrated significantly less distinct non-symbolic number representations in the anterior parietal and frontal lobes, as well as in a small spot in the temporal lobe in individuals with dyscalculia compared to controls."

Bulthé Jessica 2019 (2)¶

Bulthé Jessica, Prinsen Jellina, Vanderauwera Jolijn, Duyck Stefanie, Daniels Nicky, Gillebert Céline R., Mantini Dante, Op de Beeck Hans P., De Smedt Bert. (2019). Multi-method brain imaging reveals impaired representations of number as well as altered connectivity in adults with dyscalculia. Neuroimage, 190, 289-302. https://doi.org/10.1016/j.neuroimage.2018.06.012

q3 · i? · associational · r2

ROI-based decoding with SVM classifiers in 17 hierarchically organized ROIs confirmed the searchlight findings; e.g. All Regions non-symbolic decoding differed between groups (t46 = 2.16, p = 0.04) and IPS (pFDR = 0.048), with more distinct patterns in controls.

"For non-symbolic numbers, we found significantly less distinguishable neural representations in adults with dyscalculia compared with matched controls in the All Regions, the parietal lobe (including the IPS and right anterior IPS), the temporal lobe, and the frontal lobe (including superior and inferior frontal gyrus)."

Discussion¶

Learner Variables¶

• Learning Disabilities and Developmental Differences — predictor: learners who differ on it differ in outcomes
• Number Sense — predictor: learners who differ on it differ in outcomes

Related Claims¶

• No univariate activation-level differences between adults with dyscalculia and controls during symbolic or non-symbolic number processing — related
• Adults with dyscalculia show hyper-connectivity between primary visual cortex and inferior occipital cortex and fusiform gyrus — related
• No group difference in the quality of symbolic number representations between adults with dyscalculia and controls — related
• Neuroimaging shows adults with DD exhibit stronger frontal activations during number semantics, reduced right parietal grey matter, and altered functional connectivity during non-symbolic magnitude comparison — related