No univariate activation-level differences between adults with dyscalculia and controls during symbolic or non-symbolic number processing¶

Claim · All claims
Evidence · 1 study (2 entries) · associational r2 · q3
Currency · newest study 2019 · checked against its sources 2026-10-20 (automated, 2 of 2 entries) · not reviewed by a person · overdue for a recheck since 2024: baselines and conditions change

Subclaims¶

q3 i? Whole-brain and ROI-based univariate analyses found no significant group differences in activation for either format. → Bulthé Jessica 2019 q3 i? Subject classification with SVMs also failed to distinguish groups from whole-brain or ROI activation patterns. → Bulthé Jessica 2019 (2)

Evidence¶

Bulthé Jessica 2019¶

Bulthé Jessica, Prinsen Jellina, Vanderauwera Jolijn, Duyck Stefanie, Daniels Nicky, Gillebert Céline R., Mantini Dante, Op de Beeck Hans P., De Smedt Bert. (2019). Multi-method brain imaging reveals impaired representations of number as well as altered connectivity in adults with dyscalculia. Neuroimage, 190, 289-302. https://doi.org/10.1016/j.neuroimage.2018.06.012

q3 · i? · associational · r2

ROI-based univariate fMRI analysis in the matched adult sample; no group differences in any of the 17 ROIs (lowest pFDR = 0.10), and a whole-brain voxel-wise FWE-corrected test also found no differences.

"For the ROI-based univariate analysis, we found no significant group differences in brain activity for symbolic and non-symbolic formats in the All Regions analysis (Dots: t46 = 1.44, p = 0.11; Arabic digits: t46 = 1.86, p = 0.07)."

Bulthé Jessica 2019 (2)¶

Bulthé Jessica, Prinsen Jellina, Vanderauwera Jolijn, Duyck Stefanie, Daniels Nicky, Gillebert Céline R., Mantini Dante, Op de Beeck Hans P., De Smedt Bert. (2019). Multi-method brain imaging reveals impaired representations of number as well as altered connectivity in adults with dyscalculia. Neuroimage, 190, 289-302. https://doi.org/10.1016/j.neuroimage.2018.06.012

q3 · i? · associational · r2

SVM subject classification with leave-one-pair-out cross-validation (1000 repeats, Monte Carlo permutation testing) could not classify individuals as dyscalculic or control from activation patterns in any ROI at FDR-corrected levels.

"The results of the subject classification analysis did not show a significant subject classification accuracy, with the same patterns in the All Regions ROI, for both non-symbolic (classification accuracy = 0.57, p = 0.17) or symbolic (classification accuracy = 0.51, p = 0.45) numbers."

Discussion¶

Learner Variables¶

• Learning Disabilities and Developmental Differences — predictor: learners who differ on it differ in outcomes
• Number Sense — predictor: learners who differ on it differ in outcomes

Related Claims¶

• No white-matter structural connectivity differences between adults with dyscalculia and controls in the examined tracts — related
• Adults with dyscalculia show less distinct non-symbolic number representations than matched controls in anterior parietal, frontal and temporal cortex — related
• Neuroimaging shows adults with DD exhibit stronger frontal activations during number semantics, reduced right parietal grey matter, and altered functional connectivity during non-symbolic magnitude comparison — reports the opposite
• Adults with dyscalculia perform the number comparison task as accurately as controls but respond significantly more slowly — related
• No group difference in the quality of symbolic number representations between adults with dyscalculia and controls — related
• Adults with dyscalculia show hyper-connectivity between primary visual cortex and inferior occipital cortex and fusiform gyrus — related
• Children with DD show greater brain activation than TD children in parietal, occipito-temporal and prefrontal regions during both addition and subtraction — related
• Measures of the magnitude representation (ratio and distance effects) do not discriminate children with DD from matched controls — related