Physical exercise up-regulates neurotrophic factors and enhances neural structure and function in animals and human adults¶

Claim · All claims
Evidence · 1 study (2 entries) · review r2 · q2
Currency · newest study 2012 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? Primarily rodent evidence shows exercise up-regulates neurotrophic factors regulating neural survival, growth, differentiation, synaptogenesis, myelination, and angiogenesis. → Berwid Olga G. 2012 q2 i? In healthy human adults, exercise increases BDNF, improves cognitive performance, and promotes brain health, with strongest effects on executive functions in older adults. → Berwid Olga G. 2012 (2)

Evidence¶

Berwid Olga G. 2012¶

Berwid Olga G., Halperin Jeffrey M. (2012). Emerging Support for a Role of Exercise in Attention-Deficit/Hyperactivity Disorder Intervention Planning. Current Psychiatry Reports. https://doi.org/10.1007/s11920-012-0297-4

q2 · i? · review · r2

Narrative review of animal experimental literature. The review reports that exercise in rats increases synaptic proteins, glutamate receptors, BDNF, and insulin-like growth factor-1, and "enhance[s] spatial learning" and passive avoidance memory in rats.

"An extensive literature, primarily in rodents, provides incontrovertible evidence that physical exercise leads to the up-regulation of neurotrophic factors, which regulate neural development, including the survival, growth, and differentiation of neurons"

Berwid Olga G. 2012 (2)¶

Berwid Olga G., Halperin Jeffrey M. (2012). Emerging Support for a Role of Exercise in Attention-Deficit/Hyperactivity Disorder Intervention Planning. Current Psychiatry Reports. https://doi.org/10.1007/s11920-012-0297-4

q2 · i? · review · r2

Narrative review of human adult studies. The review reports exercise effects on catecholaminergic neurotransmission, BDNF, cognition, and brain health, noting "Physical exercise appears to exert its strongest effects on executive functions in older adults."

"Physical exercise has also been reported to facilitate catecholaminergic neurotransmission [50,51]; increase BDNF [52-58], improve cognitive performance [52,59,60], and promote brain health [61] in healthy human adults."

Discussion¶

Related Claims¶

• Exercise Increases Hippocampal Volume — a narrower finding that bears on this claim
• Daily physiological changes in non-experimental situations influence measures of brain structure and function — related
• Cognition is a transient phenomenon created by the functioning of distributed components of the nervous system — related
• Physical well-being — exercise, sleep, and nutrition — impacts learning — a broader claim this one bears on