Professionals self-report competence with clozapine guidelines but express less confidence in adhering to them¶

Claim · All claims
Evidence · 1 study · review r3 · q2
Currency · newest study 2025 · not yet checked against its sources · not reviewed by a person · recheck by 2030: baselines and conditions change

Subclaims¶

q2 i? Across included studies, HCPs self-reported as competent with local and national guidelines yet expressed less confidence in their ability to adhere to them and were uncertain about managing side effects. → Secchi Agostina 2025

Evidence¶

Secchi Agostina 2025¶

Secchi Agostina, Whiskey Eromona, Nair Sajitha, Shergill Sukhi, Thomas Trudy. (2025). Competence and confidence of health care professionals in using clozapine: a qualitative systematic review and thematic synthesis. Acta Neuropsychiatrica. https://doi.org/10.1017/neu.2025.10024

q2 · i? · review · r3

Qualitative thematic synthesis of 34 studies of health care professionals managing clozapine. The review reports that professionals "self-reported as competent with guidelines" while expressing less confidence in adherence and side-effect management. The review cautions self-report may overestimate competence.

"HCPs self-reported as competent with guidelines (local and national), yet they expressed less confidence in their ability to adhere to them and were uncertain about managing side effects."

Discussion¶

Related Claims¶

• Health care professionals show substantial knowledge gaps about clozapine side effects, especially myocarditis and seizures — related
• Misconceptions and overestimation of clozapine side effects contribute to underprescribing and prescribing variation — related
• Training improves competence in clozapine management, especially when integrated with clinical experience — related
• Exposure to clozapine use is associated with higher prescribing rates and better knowledge — related