Inhibitory CS responses prevail over excitatory ones among basolateral amygdala principal cells¶

Claim · All claims
Evidence · 1 study · theoretical r3 · q2
Currency · newest study 2017 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? In a mixed appetitive-aversive conditioning paradigm, only 7% of principal cells increased firing to the appetitive CS while most (52%) were inhibited, consistent with the engagement model. → Paré 2017

Evidence¶

Paré 2017¶

Paré, D. & Quirk, G. J. (2017). When scientific paradigms lead to tunnel vision: lessons from the study of fear. npj Science of Learning. https://doi.org/10.1038/s41539-017-0007-4

q2 · i? · theoretical · r3

Mixed appetitive-aversive conditioning paradigm recording principal cells (attributed by the article to S.C. Lee, A. Amir, D. Haufler, D. Paré, unpublished observations). The article reports "only 7% of principal cells increased their FRs" while most (52%) were inhibited, supporting the idea that expression of a response tendency requires suppressing most BL neurons.

"only 7% of principal cells increased their FRs when the appetitive CS was presented; most (52%) were inhibited"

Discussion¶

Related Claims¶

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• Experimental work indicates basolateral amygdala cells activated by appetitive CSs mainly encode behavioural output, not CS identity, challenging amygdalo-centric feedforward accounts — related