Experimental work indicates basolateral amygdala cells activated by appetitive CSs mainly encode behavioural output, not CS identity, challenging amygdalo-centric feedforward accounts¶
Claim · All claims
Evidence · 1 study · reviewr2·q2
Currency · newest study 2016 · not yet checked against its sources · not reviewed by a person
Subclaims¶
Reading the evidence codes
q is the design tier, i the impact, n the sample, and the kind with its r
the rigour judged within that kind: what each code means.
This claim: no standardized effect is recorded in observations/ for it yet, so no benchmark reading is possible.
q2 i? In rat recordings contrasting BL activity when rats produced or omitted the conditioned response, BL cells activated by appetitive CSs mainly encoded behavioural output rather than CS identity. → Nair 2016
Evidence¶
Nair 2016¶
Nair, S. S., Paré, D. and Vicentic, A. (2016). Biologically based neural circuit modelling for the study of fear learning and extinction. npj Science of Learning. https://doi.org/10.1038/npjscilearn.2016.15
q2 · i? · review · r2
The review reports this experimental finding, citing the Lee et al. single-unit study of BL responses in rats producing or omitting the conditioned response. CS-related firing was absent when rats omitted the CR and present when they emitted it, even to the wrong CS.
"it was found that BL cells activated by appetitive CSs mainly encode behavioural output, not CS identity."
Discussion¶
Related Claims¶
- Auditory input drives feed-forward inhibition onto LA interneurons, with cortical input producing a smaller E/I ratio than thalamic input — related
- Auditory thalamic and cortical input to BLA interneurons is concentrated in the LA: thalamic EPSCs are larger in LA than BA interneurons (191 vs 53 pA, p < 0.0001) — related
- NMDAR subunit stoichiometry differs between LA and BA interneurons: LA NMDAR EPSCs decay faster and LA interneurons include a GluN2A-dominant majority plus NMDAR-lacking cells, absent in the BA — related
- The timing rule of fear conditioning contradicts the Hebbian coincidence rule because simultaneous CS–US pairing is less efficient than CS onset preceding the US with co-termination tens of seconds later — related
- Glutamatergic synapses on BA interneurons are less rectifying than those on LA interneurons, indicating fewer calcium-permeable GluR2-lacking AMPARs in the BA — related
- A biophysical model suggested that more excitable LA neurons are preferentially recruited into the fear memory trace via competitive synaptic interactions, validated experimentally — related
- A biophysical LA model showed both auditory thalamic plasticity and intra-amygdala plasticity contribute to fear memory, with thalamic responsiveness essential during learning but dispensable after training — related
- Amygdala neuron activity during naturalistic foraging tracks the rat's movement, not threat, contrary to the threat-coding model — a narrower finding that bears on this claim
- Inhibitory CS responses prevail over excitatory ones among basolateral amygdala principal cells — related
- Medial prefrontal cortex gates BL amygdala activity; prelimbic and infralimbic regions show dissociable roles in platform-mediated avoidance — related
Page metadata
| Field | Value |
|---|---|
type |
claim |
id |
bl-cells-encode-behavioural-output |
title |
Experimental work indicates basolateral amygdala cells activated by appetitive CSs mainly encode behavioural output, not CS identity, challenging amygdalo-centric feedforward accounts |
description |
Experimental work indicates basolateral amygdala cells activated by appetitive CSs mainly encode behavioural output, not CS identity, challenging amygdalo-centric feedforward accounts |
status |
review |
evidence_strength |
weak |
newest_evidence |
2016 |
generated |
by process:wiki-ingest on 2026-10-26 |
trust |
unverified — no one has confirmed this page's content |
sources |
1 — nair-2016 |
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