Lower resting GABAB-mediated inhibition in M1 (measured as LICI) is strongly negatively associated with micro-offline motor consolidation gains during early learning¶

Claim · All claims
Evidence · 1 study · associational r1 · q3 · i3 large
Currency · newest study 2025 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i3 Participants with lower LICI (reflecting less GABAB-mediated inhibition, i.e. disinhibition) at rest showed better micro-offline consolidation at block T (r = −0.834, BF10 = 468). → Pasquale Cardellicchio & Sara Borgomaneri 2025

Evidence¶

Pasquale Cardellicchio & Sara Borgomaneri 2025¶

Pasquale Cardellicchio & Sara Borgomaneri. (2025). Level of M1 GABAB predicts micro offline consolidation of motor learning during wakefulness. npj Science of Learning 10:10. https://doi.org/10.1038/s41539-025-00299-1

q3 · i3 · associational · r1

Experiment with 16 right-handed adults performing a sequential finger-tapping task with 10-s practice and 10-s rest blocks; at-rest pp-TMS indices were collected before learning. Bayesian correlation showed a negative LICI–micro-offline-T relationship ("R = −0.834; BF10 = 468"), i.e. "a lower level of GABA B neurotransmitter (disinhibition) have a better motor consolidation".

"Using Bayesian correlation matrix ana- lyses, we found very strong evidence toward the H1 for a negative rela- tionship between LICI and Micro-of fline-T learning ( R = −0.834; BF10 = 468 Table1;F i g .3), such that participants who showed a lower level of GABA B neurotransmitter (disinhibition) have a better motor consolidation"

Discussion¶

Related Claims¶

• In a Bayesian linear regression, micro-offline-T learning explains a moderate proportion of variance in LICI (R² = 0.69), with moderate evidence for its inclusion — related
• The GABAB–micro-offline correlation is significantly stronger than the corresponding GABAA (SICI) correlation — related
• No other neurophysiological measure (MEP, SICI, ICF, sICF) showed a significant correlation with micro-online or micro-offline learning — related
• Performance improvements during early motor skill learning occur predominantly during short rest periods (micro-offline gains), replicated in a large crowdsourced sample and in a laboratory study — related