Medial prefrontal cortex gates BL amygdala activity; prelimbic and infralimbic regions show dissociable roles in platform-mediated avoidance¶

Claim · All claims
Evidence · 1 study (2 entries) · theoretical r3 · q2
Currency · newest study 2017 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? The strong relation between BL activity and behavior irrespective of CS identity suggests CS-related inputs from LA can be overridden by other inputs, with mPFC a prime candidate for this gating role. → Paré 2017 q2 i? In the platform-mediated avoidance task, PL inactivation reduces avoidance expression without affecting freezing, and rats that fail to extinguish avoidance show elevated BL activity and reduced IL activity. → Paré 2017 (2)

Evidence¶

Paré 2017¶

Paré, D. & Quirk, G. J. (2017). When scientific paradigms lead to tunnel vision: lessons from the study of fear. npj Science of Learning. https://doi.org/10.1038/s41539-017-0007-4

q2 · i? · theoretical · r3

The article's interpretive synthesis of Lee et al.'s finding that BL activity tracks behavior regardless of CS identity: "CS-related inputs from LA to BL can be overridden by other inputs to BL neurons", naming the medial prefrontal cortex as prime candidates for this gating role, since PL and IL are reciprocally connected with BL.

"The strong relation between BL activity and behavior irrespective of CS identity 48 suggests that the impact of CS-related inputs from LA to BL can be overridden by other inputs to BL neurons"

Paré 2017 (2)¶

Paré, D. & Quirk, G. J. (2017). When scientific paradigms lead to tunnel vision: lessons from the study of fear. npj Science of Learning. https://doi.org/10.1038/s41539-017-0007-4

q2 · i? · theoretical · r3

Platform-mediated avoidance studies (Bravo-Rivera et al., as reported here) pit shock avoidance against food retrieval. The article reports that pharmacological inactivation of PL reduces expression of avoidance but has no effect on freezing, IL inactivation impairs extinction of this avoidance, and persistent avoiders show "elevated activity in BL as well as reduced activity in IL", reflecting persistent disengagement from food-seeking.

"rats failing to extinguish platform-mediated avoidance (remaining on the platform despite the absence of shock) show elevated activity in BL as well as reduced activity in IL 73"

Discussion¶

Related Claims¶

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