Non-coding RNAs participate in learning and memory: microRNAs in fear-related learning and memory, and long non-coding RNAs regulated by experience in behavioural adaptation, as the review reports¶

Claim · All claims
Evidence · 1 study (2 entries) · review r2 · q2
Currency · newest study 2016 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? The review reports that microRNAs are critically involved in various forms of fear-related learning and memory. → Paul Marshall and Timothy W Bredy 2016 q2 i? The review reports that long non-coding RNAs are regulated by experience and appear to play a role in behavioural adaptation. → Paul Marshall and Timothy W Bredy 2016 (2)

Evidence¶

Paul Marshall and Timothy W Bredy 2016¶

Paul Marshall and Timothy W Bredy. (2016). Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory? npj Science of Learning. https://doi.org/10.1038/npjscilearn.2016.14

q2 · i? · review · r2

Narrative review stating "microRNAs are critically involved in various forms of fear-related learning and memory", citing two referenced studies on microRNA regulation of extinction and neural plasticity. The review prints no effect size for this assertion.

"For example, microRNAs are critically involved in various forms of fear-related learning and memory, 76,77"

Paul Marshall and Timothy W Bredy 2016 (2)¶

Paul Marshall and Timothy W Bredy. (2016). Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory? npj Science of Learning. https://doi.org/10.1038/npjscilearn.2016.14

q2 · i? · review · r2

Narrative review reporting that "long non-coding RNAs are also regulated by experience and appear to play a role in behavioural adaptation", citing referenced studies linking long non-coding RNA-directed epigenetic regulation to anxiety-like behaviour. Hedged as appearance of a role; no effect size printed.

"long non-coding RNAs are also regulated by experience and appear to play a role in behavioural adaptation."

Discussion¶

Related Claims¶

• The RNA modification m6A is highly dynamic in the brain and critically involved in fear memory formation, per the authors' recent work cited in the review — related
• Transfer of memory via RNA injection in Aplysia—trained donor RNA enhanced the siphon-withdrawal reflex in untrained recipients—offers the strongest challenge to date to the synaptic plasticity hypothesis — related