In multivariate-adjusted phenotypic models, all measured child/adolescent health conditions except migraine and asthma are associated with poorer GCSE attainment at 16 (ALSPAC cohort)¶
Claim · All claims
Evidence · 1 study · causalr2·q2
Currency · newest study 2021 · not yet checked against its sources · not reviewed by a person
Subclaims¶
Reading the evidence codes
q is the design tier, i the impact, n the sample, and the kind with its r
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q2 i? In phenotypic models in ALSPAC (N=6113), ADHD symptoms, depressive symptoms, autistic social traits and BMI at ages 10 and 13 were each associated with lower GCSE points scores, while migraine and asthma were not. → Hughes 2021
Evidence¶
Hughes 2021¶
Hughes, A., Wade, K. H., Dickson, M., Rice, F., Davies, A., Davies, N. M. & Howe, L. D. (2021). Common health conditions in childhood and adolescence, school absence, and educational attainment: Mendelian randomization study. npj Science of Learning 6:1. https://doi.org/10.1038/s41539-020-00080-6
q2 · i? · causal · r2
Phenotypic multivariable linear regression in the ALSPAC cohort (N=6113), adjusted for gender and family socioeconomic confounders. The article reports "all aspects of child and adolescent health were associated with GCSE points score except migraines and asthma"; Table 2 prints e.g. −25.58 points per SD SDQ-HI score at 10.
"In phenotypic models (Table 2), all aspects of child and adolescent health were associated with GCSE points score except migraines and asthma."
Discussion¶
Related Claims¶
- Genetic liability for ADHD predicts lower GCSE attainment but not greater school absence (ALSPAC cohort) — related
- Genetic instrumental-variable analysis supports a causal negative effect of higher BMI in childhood and adolescence on GCSE attainment and school absence (ALSPAC cohort) — related
- All measured health conditions are associated with greater school absence at 14–16, and depressive symptoms at 10 show a considerably stronger association with GCSEs than at 13 (ALSPAC cohort) — related
- School absence mediates health–attainment associations, least for ADHD (7.1%) and most for migraine (72.0%) and BMI (39.9%) (ALSPAC cohort) — related
- Two-sample Mendelian randomization in independent adult samples supports negative effects of BMI (and, secondarily, asthma) on years of schooling, with little evidence for migraine — related
Page metadata
| Field | Value |
|---|---|
type |
claim |
id |
phenotypic-health-gcse-associations-alspac |
title |
In multivariate-adjusted phenotypic models, all measured child/adolescent health conditions except migraine and asthma are associated with poorer GCSE attainment at 16 (ALSPAC cohort) |
description |
In multivariate-adjusted phenotypic models, all measured child/adolescent health conditions except migraine and asthma are associated with poorer GCSE attainment at 16 (ALSPAC cohort) |
status |
review |
evidence_strength |
moderate |
newest_evidence |
2021 |
generated |
by process:wiki-ingest on 2026-10-26 |
trust |
unverified — no one has confirmed this page's content |
sources |
1 — hughes-2021 |
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