Lower SES adolescents show greater stress-related increase in serotonin transporter gene methylation, associated with greater amygdala reactivity and depression symptoms¶
Claim · All claims
Evidence · 1 study · theoreticalr3·q2
Currency · newest study 2017 · not yet checked against its sources · not reviewed by a person · overdue for a recheck since 2022: baselines and conditions change
Subclaims¶
Reading the evidence codes
q is the design tier, i the impact, n the sample, and the kind with its r
the rigour judged within that kind: what each code means.
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q2 i? Across two time-points, lower SES teenagers showed greater increases in methylation of the serotonin transporter gene than higher SES peers, associated with greater amygdala reactivity and more depression symptoms. → Martha J. Farah 2017
Evidence¶
Martha J. Farah 2017¶
Martha J. Farah. (2017). Socioeconomic status and the brain: prospects for neuroscience-informed policy. https://doi.org/10.1038/s41583-018-0023-2
q2 · i? · theoretical · r3
The Perspective reports, citing a longitudinal multimethod study of stress-related methylation of the serotonin transporter gene in adolescents, that "teenagers with lower SES showed a greater increase in methylation than their higher SES peers". No effect size is printed.
"Across two time-points, teenagers with lower SES showed a greater increase in methylation than their higher SES peers and this was associated with greater amygdala reactivity and more depression symptoms."
Discussion¶
Related Claims¶
- Chronicity, developmental timing, and intensity of adversity exposure shape children's neurobiological stress responses — related
- Early life stress produces structural and functional alterations in prefrontal-hippocampal-amygdala circuits in animals and humans, with reduced hippocampal volume among the most reliable human findings — related
- Higher serotonin is associated with persisting in challenging situations, and serotonin synthesis is greater when tryptophan is consumed in the morning or early afternoon — related
- Unpredictability and lack of contingent caregiver responding in childhood is associated with increased adolescent externalizing behaviors and altered prefrontal-hippocampal-amygdala circuits — related
Page metadata
| Field | Value |
|---|---|
type |
claim |
id |
ses-linked-methylation-amygdala-reactivity-depression |
title |
Lower SES adolescents show greater stress-related increase in serotonin transporter gene methylation, associated with greater amygdala reactivity and depression symptoms |
description |
Lower SES adolescents show greater stress-related increase in serotonin transporter gene methylation, associated with greater amygdala reactivity and depression symptoms |
status |
review |
evidence_strength |
weak |
newest_evidence |
2017 |
recheck_by |
2022 |
generated |
by process:wiki-ingest on 2026-10-17 |
trust |
unverified — no one has confirmed this page's content |
sources |
1 — martha-j-farah-2017 |
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