Chronicity, developmental timing, and intensity of adversity exposure shape children's neurobiological stress responses¶

Claim · All claims
Evidence · 1 study · review r2 · q2
Currency · newest study 2020 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? Children with high Life Stress Interview scores have smaller amygdala and hippocampal volumes, and retrospectively reported severity of early stress is associated with increased dorsal medial PFC responses to a social stressor and altered ventrolateral PFC connectivity. → Karen E. Smith and Seth D. Pollak 2020

Evidence¶

Karen E. Smith and Seth D. Pollak 2020¶

Karen E. Smith and Seth D. Pollak. (2020). Early life stress and development: potential mechanisms for adverse outcomes. Journal of Neurodevelopmental Disorders. https://doi.org/10.1186/s11689-020-09337-y

q2 · i? · review · r2

Narrative review synthesis of studies on adversity intensity. The review reports "Children with high scores on the Life Stress Interview (LSI), which quantifies the intensity of children’s stress exposure, have smaller amygdala and hippocampal volumes than children exposed to less intense levels of early life stress." No effect sizes are printed.

"Children with high scores on the Life Stress Interview (LSI), which quantifies the intensity of children’s stress exposure, have smaller amygdala and hippocampal volumes than children exposed to less in- tense levels of early life stress [ 29]."

Discussion¶

Related Claims¶

• Early life stress produces structural and functional alterations in prefrontal-hippocampal-amygdala circuits in animals and humans, with reduced hippocampal volume among the most reliable human findings — related
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