Typical readers show significantly greater rate-related activation gains than dyslexic readers in left prefrontal and left superior temporal regions¶
Claim · All claims
Evidence · 1 study · causalr1·q3
Currency · newest study 2014 · not yet checked against its sources · not reviewed by a person
Subclaims¶
Reading the evidence codes
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q3 i? On the parametric Fast > Medium > Slow contrast, typical readers showed greater activation than dyslexic readers in left middle frontal gyrus, left superior temporal gyrus, and brainstem/cerebellar clusters, while dyslexic readers showed no greater activation than typical readers. → Christodoulou JA 2014
Evidence¶
Christodoulou JA 2014¶
Christodoulou JA, Del Tufo SN, Lymberis J, Saxler PK, Ghosh SS, et al. (2014) Brain Bases of Reading Fluency in Typical Reading and Impaired Fluency in Dyslexia. PLoS ONE 9(7): e100552. https://doi.org/10.1371/journal.pone.0100552
q3 · i? · causal · r1
Whole-brain parametric modulation analysis (cluster-level FDR corrected, p<.01) compared groups on the Fast > Medium > Slow contrast. Typical readers showed greater activation in left middle frontal, left superior temporal, and brainstem/cerebellar clusters; "Readers with dyslexia did not show any activation greater than typical readers".
"Compared to readers with dyslexia on the parametric analysis (Fast . Medium . Slow), typical readers showed greater activation in a cluster with a peak in left middle frontal gyrus that extended into the inferior frontal gyrus, insula, and precentral gyrus; a cluster with a peak in left superior temporal gyrus"
Discussion¶
Related Claims¶
- Group differences in activation are more extensive when behavioral performance is equated across groups, indicating they are not a consequence of worse performance — related
- In-scanner sentence judgment accuracy declines with faster word presentation rates, and dyslexic readers' accuracy declines disproportionately across rates — related
- Typical readers respond faster than dyslexic readers overall, and responses slow as presentation rates increase, without a group-by-rate interaction for reaction time — related
- Individuals with dyslexia show impairments in audiovisual integration beyond phoneme-grapheme mapping — related
- Individuals with schizophrenia show reduced behavioral benefit from combined audiovisual cues and altered multisensory temporal processing — related
Page metadata
| Field | Value |
|---|---|
type |
claim |
id |
typical-readers-greater-rate-activation-gains-left-frontotemporal |
title |
Typical readers show significantly greater rate-related activation gains than dyslexic readers in left prefrontal and left superior temporal regions |
description |
Typical readers show significantly greater rate-related activation gains than dyslexic readers in left prefrontal and left superior temporal regions |
status |
review |
evidence_strength |
moderate |
newest_evidence |
2014 |
generated |
by process:wiki-ingest on 2026-10-17 |
trust |
unverified — no one has confirmed this page's content |
sources |
1 — christodoulou-ja-2014 |
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