The common factor shows significant genetic correlations with six psychiatric disorders and six behavioral traits, strongest with PTSD (rg = -0.47) and educational attainment (rg = 0.74)¶

Claim · All claims
Evidence · 1 study · associational r2 · q2
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? Cg has significant genetic correlations with six psychiatric disorders (rg = -0.47 to 0.24) and six behavioral traits (rg = 0.31 to 0.74), with the strongest correlations for PTSD (rg = -0.47, SE = 0.07) and educational attainment (rg = 0.74, SE = 0.03). No standardized effect size statistic is printed for these correlations. → Shiying Wang 2026

Evidence¶

Shiying Wang 2026¶

Shiying Wang, Joan Bosson-Heenan, Andrew Grotzinger, Jan C. Frijters & Jeffrey R. Gruen. (2026). Shared genetic architecture of reading and attention disorders using genomic structural equation modeling. npj Science of Learning. https://doi.org/10.1038/s41539-026-00433-7

q2 · i? · associational · r2

LDSC genetic correlation analysis of Cg summary statistics against PGC and UK Biobank GWAS of psychiatric disorders, behavioral traits, and brain morphology metrics. The article prints "The strongest genetic correlation was with educational attainment (rg=0.74, SE = 0.03)" and "post-traumatic stress disorder (rg=- 0.47, SE = 0.07)" as genetic correlations with standard errors; no standardized effect size statistic is printed.

"Cg had modest but significant genetic correlations with six psychiatric disorders (rg ranges from -0.47 to 0.24). The strongest genetic correlation was with post-traumatic stress disorder (rg=- 0.47, SE = 0.07). There were significant modest-to-high genetic correlations with six behavioral traits (rg ranges from 0.31 to 0.74). The strongest genetic correlation was with educational attainment (rg=0.74, SE = 0.03)."

Discussion¶

Related Claims¶

• Stratified Genomic SEM finds the common factor enriched only in primate-conserved genomic regions — related
• A multivariate GWAS on the common factor identifies a genome-wide significant locus on chromosome 12q13.12 that no univariate trait GWAS detected — related
• The common factor model is specific to reading and ADHD rather than broader psychiatric liability, and stability analyses support the reading-ADHD structure — related
• A common genetic factor captures shared genetic influences across four reading-related traits and ADHD, with ADHD loading negatively and reading traits positively — related