A multivariate GWAS on the common factor identifies a genome-wide significant locus on chromosome 12q13.12 that no univariate trait GWAS detected¶

Claim · All claims
Evidence · 1 study · associational r2 · q2
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? GWAS predicated on the common factor Cg identifies rs7969091 at genome-wide significance, whereas the same SNP is not genome-wide significant in univariate GWAS of any individual trait. → Shiying Wang 2026

Evidence¶

Shiying Wang 2026¶

Shiying Wang, Joan Bosson-Heenan, Andrew Grotzinger, Jan C. Frijters & Jeffrey R. Gruen. (2026). Shared genetic architecture of reading and attention disorders using genomic structural equation modeling. npj Science of Learning. https://doi.org/10.1038/s41539-026-00433-7

q2 · i? · associational · r2

Multivariate GWAS of SNP effects on the common genetic factor Cg, computed from 6,421,479 SNPs after quality control. The article reports rs7969091 reached genome-wide significance (p = 3.86 × 10−8) and states "No genome-wide significant associations were observed for individual traits." No effect size is printed.

"One locus within 12q13.12 achieved genome-wide significance with the top SNP, rs7969091 (minor allele frequency (MAF) = 0.417, 𝑝-value = 3.86 × 10−8; Figure 3A)."

Discussion¶

Related Claims¶

• Stratified Genomic SEM finds the common factor enriched only in primate-conserved genomic regions — related
• The common factor shows significant genetic correlations with six psychiatric disorders and six behavioral traits, strongest with PTSD (rg = -0.47) and educational attainment (rg = 0.74) — related
• Transcriptome-wide SEM links the common factor to tissue-specific expression of RHEBL1 and LMBR1L within the same 12q13.12 locus — a narrower finding that bears on this claim
• SuSiE fine-mapping of the common-factor locus resolves the signal into a 95% credible set of 22 variants near RHEBL1 — a narrower finding that bears on this claim