Stratified Genomic SEM finds the common factor enriched only in primate-conserved genomic regions¶
Claim · All claims
Evidence · 1 study · associationalr2·q2
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person
Subclaims¶
Reading the evidence codes
q is the design tier, i the impact, n the sample, and the kind with its r
the rigour judged within that kind: what each code means.
This claim: no standardized effect is recorded in observations/ for it yet, so no benchmark reading is possible.
q2 i? Across 50 binary functional genomic annotations, only primate-conserved regions reach Bonferroni-corrected enrichment significance for Cg. → Shiying Wang 2026
Evidence¶
Shiying Wang 2026¶
Shiying Wang, Joan Bosson-Heenan, Andrew Grotzinger, Jan C. Frijters & Jeffrey R. Gruen. (2026). Shared genetic architecture of reading and attention disorders using genomic structural equation modeling. npj Science of Learning. https://doi.org/10.1038/s41539-026-00433-7
q2 · i? · associational · r2
Stratified Genomic SEM using 50 binary annotations from the BaselineLD Version 2.2 model. The article reports an enrichment ratio of 14.62 (SE = 3.92, p = 2.5 × 10⁻⁴) for primate-conserved regions; no standardized effect size is printed.
"Only primate-conserved regions (conserved_primate_phastcons46way) reached Bonferroni-corrected significance (enrichment ratio = 14.62, SE = 3.92, p = 2.5 × 10⁻⁴), indicating that SNPs in genomic regions conserved across primate species contribute disproportionately to the shared genetic architecture captured by Cg."
Discussion¶
Related Claims¶
- Transcriptome-wide SEM links the common factor to tissue-specific expression of RHEBL1 and LMBR1L within the same 12q13.12 locus — related
- A multivariate GWAS on the common factor identifies a genome-wide significant locus on chromosome 12q13.12 that no univariate trait GWAS detected — related
- SuSiE fine-mapping of the common-factor locus resolves the signal into a 95% credible set of 22 variants near RHEBL1 — related
- The common factor shows significant genetic correlations with six psychiatric disorders and six behavioral traits, strongest with PTSD (rg = -0.47) and educational attainment (rg = 0.74) — related
- A common genetic factor captures shared genetic influences across four reading-related traits and ADHD, with ADHD loading negatively and reading traits positively — a broader claim this one bears on
Page metadata
| Field | Value |
|---|---|
type |
claim |
id |
cg-enrichment-primate-conserved-regions |
title |
Stratified Genomic SEM finds the common factor enriched only in primate-conserved genomic regions |
description |
Stratified Genomic SEM finds the common factor enriched only in primate-conserved genomic regions |
status |
review |
evidence_strength |
weak |
newest_evidence |
2026 |
generated |
by process:wiki-ingest on 2026-10-26 |
trust |
unverified — no one has confirmed this page's content |
sources |
1 — shiying-wang-2026 |
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