Educational attainment polygenic scores are positively associated with childhood visual acuity, while myopia polygenic scores show a negative association¶

Claim · All claims
Evidence · 1 study · associational r3 · q3 · i0 negligible
Currency · newest study 2023 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i0 Myopia PGS shows the opposite-sign association, with a 1 SD increase associated with a 0.05 SD decrease in visual acuity. → Schmitz 2023

Evidence¶

Schmitz 2023¶

Schmitz, J., Abbondanza, F., Marianski, K., Luciano, M. & Paracchini, S. (2023). Identification of loci involved in childhood visual acuity and associations with cognitive skills and educational attainment. npj Science of Learning, 8:25. https://doi.org/10.1038/s41539-023-00175-w

q3 · i0 · associational · r3

Same PGS regression analysis; the myopia PGS association (standardised β = −0.05, p = 0.0002) was Bonferroni-significant, though the article describes it as a less robust negative association than the EA PGS effect.

"In contrast, myopia PGS showed a negative association with visual acuity with 1 SD increase in myopia PGS associated with a 0.05 SD decrease in visual acuity (Table 2)."

Discussion¶

Related Claims¶

• Polygenic scores based on the Lee et al. (2018) GWAS show a meta-analytic association of ρ = 0.27 with educational attainment — a broader claim this one bears on
• Polygenic scores show a meta-analytic association of ρ = 0.24 with educational achievement — a broader claim this one bears on
• Children in higher SES families have higher average polygenic scores for educational attainment — related
• GWAS identifies genome-wide significant association of childhood visual acuity at the NPLOC4 locus on chromosome 17 — related