Polygenic scores based on the Lee et al. (2018) GWAS show a meta-analytic association of ρ = 0.27 with educational attainment¶

Claim · All claims
Evidence · 1 study · quant-synthesis r2 · q4 · i2 medium
Currency · newest study 2024 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q4 i2 Across 20 estimates from 16 samples, polygenic scores are positively associated with educational attainment with a pooled ρ = 0.27 (95% CI 0.22–0.32). → Wilding 2024

Evidence¶

Wilding 2024¶

Wilding, K., Wright, M., & von Stumm, S. (2024). Using DNA to Predict Education: a Meta-analytic Review. Educational Psychology Review. https://doi.org/10.1007/s10648-024-09928-4

q4 · i2 · quant-synthesis · r2

Preregistered three-level multilevel meta-analysis (metafor rma.mv) of studies reporting associations between polygenic scores from the Lee et al. (2018) GWAS and educational attainment; the pooled estimate was ρ = 0.27, p < 0.001, "reflecting a positive relation of large effect size".

"The meta-analytic association between polygenic scores and educational attainment was ρ = 0.27, p < 0.001 (95% CI from 0.22 to 0.32), reflecting a positive relation of large effect size"

Discussion¶

Related Claims¶

• Polygenic scores show a meta-analytic association of ρ = 0.24 with educational achievement
• Polygenic score predictions of education strengthen as GWAS discovery sample sizes increase
• Polygenic score predictions are reduced in African American relative to European ancestry samples, significantly so only for educational attainment
• Sample ancestry significantly moderates polygenic score predictions of educational attainment, with stronger predictions in European-ancestry samples — related
• Age at assessment and achievement measure moderate polygenic score predictions of educational achievement; the adjusted pooled estimate rises to ρ = 0.50 — related
• Only 15% of published polygenic score estimates for education come from non-European ancestry samples, all recruited in the US — related