Exploratory whole-brain voxel-wise analysis reveals a decrease in SV2A tracer binding in the left temporal pole from PRE to POST, to be interpreted with caution¶

Claim · All claims
Evidence · 1 study · causal r1 · q2
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? An exploratory voxel-wise SPM12 analysis revealed decreased SV2A tracer binding in the left temporal pole and several regions associated with learning progress. → Hehl 2026

Evidence¶

Hehl 2026¶

Hehl, M., Toyonaga, T., Carson, R. E., Dupont, P., Van Laere, K., Swinnen, S. P. & Cuypers, K. (2026). No significant changes in synaptic density and gray matter volume following motor learning—a pilot study. npj Science of Learning. https://doi.org/10.1038/s41539-026-00451-5

q2 · i? · causal · r1

Exploratory voxel-wise SPM12 analysis of SV2A binding and GM changes in the pilot sample, performed because VOI averaging loses within-VOI spatial information. The article also reports several brain regions showing associations between SV2A binding and motor learning progress, but stresses these results "should be interpreted with caution".

"this exploratory supplemental analysis revealed a decrease in SV2A tracer binding in the left temporal pole from PRE to POST measurement"

Discussion¶

Related Claims¶

• Baseline cortical thickness in (pre)SMA is positively associated with baseline SV2A tracer binding, but no other VOIs show this relationship and changes in GM are not associated with changes in SV2A binding — related
• No significant longitudinal changes in SV2A tracer binding in six visuomotor VOIs after four weeks of motor learning, and no associations between SV2A binding and learning progress — related
• No significant longitudinal changes in gray matter volume or cortical thickness in the visuomotor VOIs, and no associations between GM metrics and learning progress — related