Baseline cortical thickness in (pre)SMA is positively associated with baseline SV2A tracer binding, but no other VOIs show this relationship and changes in GM are not associated with changes in SV2A binding¶

Claim · All claims
Evidence · 1 study · causal r1 · q3
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i? Baseline aCT (corrected for eTIV) was positively associated with baseline SV2A tracer uptake in (pre)SMA only. → Hehl 2026

Evidence¶

Hehl 2026¶

Hehl, M., Toyonaga, T., Carson, R. E., Dupont, P., Van Laere, K., Swinnen, S. P. & Cuypers, K. (2026). No significant changes in synaptic density and gray matter volume following motor learning—a pilot study. npj Science of Learning. https://doi.org/10.1038/s41539-026-00451-5

q3 · i? · causal · r1

Multiple linear regression per VOI in the 22-participant pilot. No association was found in DLPFC, hMT/V5+, PMd and SM1 (all p > 0.05), nor between baseline GMV and baseline SV2A binding (all p > 0.15), nor between changes in GM metrics and changes in SV2A uptake (all p > 0.37 for GMV; p > 0.22 for aCT).

"baseline aCT (corrected for eTIV) was positively associated with baseline SV2A tracer uptake in (pre)SMA (model: F = 4.340, p = 0.0280, adj. R2 = 0.2413; main effect of SUVR at baseline: β = 0.1446, p = 0.0169)"

Discussion¶

Related Claims¶

• Exploratory whole-brain voxel-wise analysis reveals a decrease in SV2A tracer binding in the left temporal pole from PRE to POST, to be interpreted with caution — related
• No significant longitudinal changes in gray matter volume or cortical thickness in the visuomotor VOIs, and no associations between GM metrics and learning progress — related
• No significant longitudinal changes in SV2A tracer binding in six visuomotor VOIs after four weeks of motor learning, and no associations between SV2A binding and learning progress — related