No significant longitudinal changes in SV2A tracer binding in six visuomotor VOIs after four weeks of motor learning, and no associations between SV2A binding and learning progress¶

Claim · All claims
Evidence · 1 study (2 entries) · associational r1 · q3
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i? Neither GROUP, TIMING nor their interaction significantly influenced SUVR in any VOI. → Hehl 2026 q3 i? No correlations were found between baseline or change in SUVR and BTT training progress, pooled or per group. → Hehl 2026 (2)

Evidence¶

Hehl 2026¶

Hehl, M., Toyonaga, T., Carson, R. E., Dupont, P., Van Laere, K., Swinnen, S. P. & Cuypers, K. (2026). No significant changes in synaptic density and gray matter volume following motor learning—a pilot study. npj Science of Learning. https://doi.org/10.1038/s41539-026-00451-5

q3 · i? · causal · r1

Linear mixed models per VOI on [18F]SynVesT-1 SUVR (PRE vs POST) in the 22-participant pilot, with SUBJECT as random effect and GROUP and TIMING as fixed effects. No main effects or interaction reached significance in any of the six visuomotor VOIs.

"Neither GROUP, nor TIMING, nor their interaction significantly influenced SUVR in any of the VOIs (main effect TIMING: all,p > 0.23)"

Hehl 2026 (2)¶

Hehl, M., Toyonaga, T., Carson, R. E., Dupont, P., Van Laere, K., Swinnen, S. P. & Cuypers, K. (2026). No significant changes in synaptic density and gray matter volume following motor learning—a pilot study. npj Science of Learning. https://doi.org/10.1038/s41539-026-00451-5

q3 · i? · associational · r1

Correlation analyses between baseline SUVR or SUVR change and BTT training progress in the same pilot. For both groups pooled, all p > 0.24 and |r| < 0.26; per group, all p > 0.17 and |r| < 0.45. No effect sizes were reported as significant.

"There were no correlations between SUVRPRE and BTT training progress"

Discussion¶

Related Claims¶

• Exploratory whole-brain voxel-wise analysis reveals a decrease in SV2A tracer binding in the left temporal pole from PRE to POST, to be interpreted with caution — related
• No significant longitudinal changes in gray matter volume or cortical thickness in the visuomotor VOIs, and no associations between GM metrics and learning progress — related
• Baseline cortical thickness in (pre)SMA is positively associated with baseline SV2A tracer binding, but no other VOIs show this relationship and changes in GM are not associated with changes in SV2A binding — related