A biophysical LA model showed both auditory thalamic plasticity and intra-amygdala plasticity contribute to fear memory, with thalamic responsiveness essential during learning but dispensable after training¶

Claim · All claims
Evidence · 1 study · review r2 · q2
Currency · newest study 2016 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? In the biophysical amygdala model, increases in CS responsiveness of auditory thalamic neurons were essential for fear learning, while after training the fear memory was maintained by post-synaptic increases in synaptic efficacy within LA. → Nair 2016

Evidence¶

Nair 2016¶

Nair, S. S., Paré, D. and Vicentic, A. (2016). Biologically based neural circuit modelling for the study of fear learning and extinction. npj Science of Learning. https://doi.org/10.1038/npjscilearn.2016.15

q2 · i? · review · r2

Simulation result of the biophysically realistic LA network model described in the review. The authors report that the model unexpectedly reconciled the afferent-plasticity and intra-amygdala-plasticity views: "the fear memory was maintained by post-synaptic increases in synaptic ef ficacy within LA" after training.

"while increases in the CS responsiveness of auditory thalamic neurons were found to be essential for fear learning in the model, after training they were no longer needed because the fear memory was maintained by post-synaptic increases in synaptic ef ficacy within LA."

Discussion¶

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