READ1 RU2Short presence significantly predicts poor comprehension despite adequate word reading after covariate control¶

Claim · All claims
Evidence · 1 study · associational r2 · q3 · i1 small
Currency · newest study 2018 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i1 In a multinomial logistic regression controlling for age, vocabulary, sex, maternal education, home language, bilingual status, SES, and ancestry PCs, READ1 RU2Short presence significantly predicted UPC membership (UGC vs. UPC OR = 0.6; 95% CI [0.38 0.95]). → Li 2018

Evidence¶

Li 2018¶

Li, M., Malins, J. G., DeMille, M. M. C., Lovett, M. W., Truong, D. T., Epstein, K., Lacadie, C., Mehta, C., Bosson-Heenan, J., Gruen, J. R., Frijters, J. C. and the GRaD Study Consortium. (2018). A molecular-genetic and imaging-genetic approach to specific comprehension difficulties in children. npj Science of Learning 3:20. https://doi.org/10.1038/s41539-018-0034-9

q3 · i1 · associational · r2

Multinomial logistic regression predicting comprehension group membership (UPC reference), accounting for 19.7% of variance (Nagelkerke pseudo R2). Vocabulary (UGC vs. UPC OR = 5.28) and younger age were also significant predictors.

"Controlling for all these factors, our target variable – the presence of READ1 RU2Short alleles – was also a signi ficant predictor of having poor comprehension skills despite adequate word reading (OR = 0.6; 95% CI [0.38 0.95])."

Discussion¶

Related Claims¶

• RU2Short READ1 genotype proportions differ significantly across comprehension groups, highest in UPC — related
• Functional connectivity between right insula/IFG and right SMG is stronger in children with RU2Short alleles — related
• Children with unexpected poor comprehension show a profound vocabulary deficit despite average-to-above-average word reading — related
• Phonological awareness mediates the effect of the DCDC2-READ1 RU2-Short allele on word reading accuracy, word reading fluency, and reading comprehension — related