Functional connectivity between right insula/IFG and right SMG is stronger in children with RU2Short alleles¶

Claim · All claims
Evidence · 1 study · associational r2 · q2
Currency · newest study 2018 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? Resting-state functional connectivity between the right insula/IFG seed and the right supramarginal gyrus was stronger in subjects with RU2Short alleles than in subjects without them (B = .077, p = .042). → Li 2018

Evidence¶

Li 2018¶

Li, M., Malins, J. G., DeMille, M. M. C., Lovett, M. W., Truong, D. T., Epstein, K., Lacadie, C., Mehta, C., Bosson-Heenan, J., Gruen, J. R., Frijters, J. C. and the GRaD Study Consortium. (2018). A molecular-genetic and imaging-genetic approach to specific comprehension difficulties in children. npj Science of Learning 3:20. https://doi.org/10.1038/s41539-018-0034-9

q2 · i? · associational · r2

Multiple regression of READ1 genotype on connectivity strength for four network nodes in the 58-child fMRI subset, with sex and/or SES as covariates from backward selection. Table 5 reports the right SMG effect (B = .077, SE = .037, p = .042).

"That is, functional connectivity between the right insula/IFG and the right SMG was stronger in subjects with RU2Short alleles than it was in subjects without RU2Short alleles."

Discussion¶

Related Claims¶

• Right insula/IFG intrinsic connectivity is negatively associated with comprehension residuals in resting-state fMRI — related
• READ1 RU2Short presence significantly predicts poor comprehension despite adequate word reading after covariate control — related
• Task and interpersonal interdependence interact on inter-brain synchrony in the right supramarginal gyrus — related