Chronic stress generally decreases adult hippocampal neurogenesis, but some studies report no effect or increases, with effects moderated by stressor, species, sex and strain¶

Claim · All claims
Evidence · 1 study · review r3 · q2
Currency · newest study 2022 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? Stress generally decreases cell proliferation and newborn neuron survival in the adult hippocampus, though several studies report no effect or stress-induced increases, moderated by stressor nature, duration, species, sex and strain. → Katherine L. Jones 2022

Evidence¶

Katherine L. Jones 2022¶

Katherine L. Jones, Mei Zhou and Dhanisha J. Jhaveri. (2022). Dissecting the role of adult hippocampal neurogenesis towards resilience versus susceptibility to stress-related mood disorders. npj Science of Learning 7:16. https://doi.org/10.1038/s41539-022-00133-y

q2 · i? · review · r3

Narrative review summarising rodent studies across stress paradigms (chronic unpredictable mild stress, social defeat, restraint, corticosterone administration). The review reports that decreases are common but that "studies that show no effects of stress on hippocampal cell proliferation" exist, with some reporting increases.

"However, there have also been studies that show no effects of stress on hippocampal cell proliferation 48–51, with some even reporting an increase in hippocampal neurogenesis following stress52–54."

Discussion¶

Related Claims¶

• Whether adult-born hippocampal neurons buffer or exacerbate the behavioural and endocrine effects of chronic stress remains unresolved, with conflicting ablation findings — related
• Genetic or chemogenetic enhancement of adult hippocampal neurogenesis does not improve baseline mood but can promote behavioural resilience to chronic stressors — related
• Chronic, but not acute, administration of clinical antidepressants enhances adult hippocampal neurogenesis across multiple stages of the neurogenic process
• The single study reporting enhanced performance under stress may reflect stressors that failed to induce sufficient stress — related