Chronic, but not acute, administration of clinical antidepressants enhances adult hippocampal neurogenesis across multiple stages of the neurogenic process¶
Claim · All claims
Evidence · 1 study · reviewr2·q2
Currency · newest study 2022 · not yet checked against its sources · not reviewed by a person · recheck by 2027: baselines and conditions change
Subclaims¶
Reading the evidence codes
q is the design tier, i the impact, n the sample, and the kind with its r
the rigour judged within that kind: what each code means.
This claim: no standardized effect is recorded in observations/ for it yet, so no benchmark reading is possible.
q2 i? Different classes of antidepressants increase cell proliferation and enhance adult hippocampal neurogenesis, an effect requiring chronic rather than acute administration. → Katherine L. Jones 2022
Evidence¶
Katherine L. Jones 2022¶
Katherine L. Jones, Mei Zhou and Dhanisha J. Jhaveri. (2022). Dissecting the role of adult hippocampal neurogenesis towards resilience versus susceptibility to stress-related mood disorders. npj Science of Learning 7:16. https://doi.org/10.1038/s41539-022-00133-y
q2 · i? · review · r2
Narrative review citing rodent studies of tranylcypromine, fluoxetine, reboxetine and electroconvulsive therapy, which the review reports increased proliferation and enhanced neurogenesis. The replicated finding is the "requirement of chronic but not acute administration".
"These findings were replicated in several subsequent studies which highlighted the requirement of chronic but not acute administration of these clinical antidepressants to produce the neurogenic effect 56–59."
Discussion¶
Related Claims¶
- Ablation of adult hippocampal neurogenesis blocks the anxiolytic effects of some antidepressants, indicating adult-born neurons are required for some antidepressant efficacy — related
- Ablating adult hippocampal neurogenesis in naive non-stressed rodents has equivocal effects on baseline anxiety- and depression-like behaviour, specific to ablation model and behavioural test — related
- Genetic or chemogenetic enhancement of adult hippocampal neurogenesis does not improve baseline mood but can promote behavioural resilience to chronic stressors
- Chronic stress generally decreases adult hippocampal neurogenesis, but some studies report no effect or increases, with effects moderated by stressor, species, sex and strain
- Whether adult-born hippocampal neurons buffer or exacerbate the behavioural and endocrine effects of chronic stress remains unresolved, with conflicting ablation findings
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review |
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by process:wiki-ingest on 2026-10-26 |
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