Whether adult-born hippocampal neurons buffer or exacerbate the behavioural and endocrine effects of chronic stress remains unresolved, with conflicting ablation findings¶

Claim · All claims
Evidence · 1 study · review r3 · q2
Currency · newest study 2022 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? Non-specific ablation studies mostly report no change in stress susceptibility, but individual studies support both stress-buffering roles (genetic ablation enhancing glucocorticoid response and anxiety) and susceptibility-promoting roles (ablation blocking stress-induced social avoidance). → Katherine L. Jones 2022

Evidence¶

Katherine L. Jones 2022¶

Katherine L. Jones, Mei Zhou and Dhanisha J. Jhaveri. (2022). Dissecting the role of adult hippocampal neurogenesis towards resilience versus susceptibility to stress-related mood disorders. npj Science of Learning 7:16. https://doi.org/10.1038/s41539-022-00133-y

q2 · i? · review · r3

Narrative review of stressed-animal ablation studies (Table 2). The review reports both buffering (genetic models: blocking neurogenesis enhanced glucocorticoid response and anxiety-like behaviour) and susceptibility-promoting results (ablation preventing social defeat-induced avoidance; fluoxetine-enhanced neurogenesis increasing vulnerability).

"Based on these conflicting findings, the question of whether adult-born neurons in the hippocampus buffer or exacerbate the behavioural and endocrine effects of stress remains unresolved."

Discussion¶

Related Claims¶

• Ablating adult hippocampal neurogenesis in naive non-stressed rodents has equivocal effects on baseline anxiety- and depression-like behaviour, specific to ablation model and behavioural test — related
• Genetic or chemogenetic enhancement of adult hippocampal neurogenesis does not improve baseline mood but can promote behavioural resilience to chronic stressors — related
• Chronic stress generally decreases adult hippocampal neurogenesis, but some studies report no effect or increases, with effects moderated by stressor, species, sex and strain — related
• Ablation of adult hippocampal neurogenesis blocks the anxiolytic effects of some antidepressants, indicating adult-born neurons are required for some antidepressant efficacy
• Chronic, but not acute, administration of clinical antidepressants enhances adult hippocampal neurogenesis across multiple stages of the neurogenic process