Top SNPs and genes from prior dyslexia and Chinese reading GWAS show significant overlap with the Hong Kong sample's phenotypes, especially Chinese vocabulary breadth¶

Claim · All claims
Evidence · 1 study · associational r2 · q2
Currency · newest study 2024 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? SNP-set tests showed significant overlap of CVB_Total susceptibility SNPs with dyslexia SNPs from an independent GWAS, and gene-set tests based on prior dyslexia GWAS top genes were significant for multiple reading/language phenotypes. → Yu-Ping Lin 2024

Evidence¶

Yu-Ping Lin 2024¶

Yu-Ping Lin, Yujia Shi, Ruoyu Zhang, Xiao Xue, Shitao Rao, Liangying Yin, Kelvin Fai Hong Lui, Dora Jue Pan, Urs Maurer, Kwong-Wai Choy, Silvia Paracchini, Catherine McBride & Hon-Cheong So. (2024). A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children. npj Science of Learning. https://doi.org/10.1038/s41539-024-00229-7

q2 · i? · associational · r2

SNP-set and gene-set overlap analyses (Simes and ACAT tests) against top SNPs/genes from Doust et al. and Wang et al.; the entry quotes the finding that "CVB_Total showed signi ficant overlap with those identified for dyslexia", with some evidence for CWR_Norm; gene-set results were significant for phenotypes including CVB_Total, CVD_Total, CVK_Total, CDICT_Total, CCR_Total and MS_Total.

"the identified susceptibility SNPs for CVB_Total showed signi ficant overlap with those identified for dyslexia in an independent GWAS8. There is also some evidence for overlap for CWR_Norm."

Discussion¶

Learner Variables¶

• Vocabulary — predictor: learners who differ on it differ in outcomes

Related Claims¶

• Gene-based tests identify associations including KCNC1 with pure-tone phonological composite, GTF3C1 with Chinese vocabulary measures, and CATSPERD with English word reading — related
• Hong Kong sample phenotypes show genetic dependence with GenLang reading traits, with 42 of 170 trait pairs reaching nominal significance and 22 reaching FDR < 0.1, mostly with word reading — related
• Five independent loci reach genome-wide significance for language/literacy phenotypes including Chinese vocabulary, character and word reading, rapid digit naming, and English lexical decision in Hong Kong Chinese bilingual children — related
• The most significant single-variant association is rs6905617 with English Lexical Decision (p = 3.29E-09), located near MANEA and MANEA-AS1 — related