Hong Kong sample phenotypes show genetic dependence with GenLang reading traits, with 42 of 170 trait pairs reaching nominal significance and 22 reaching FDR < 0.1, mostly with word reading¶

Claim · All claims
Evidence · 1 study · associational r2 · q2
Currency · newest study 2024 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? Hoeffding's test of independence on full GWAS summary statistics showed genetic overlap between multiple Hong Kong Chinese/ESL phenotypes and GenLang reading/language traits, especially word reading. → Yu-Ping Lin 2024

Evidence¶

Yu-Ping Lin 2024¶

Yu-Ping Lin, Yujia Shi, Ruoyu Zhang, Xiao Xue, Shitao Rao, Liangying Yin, Kelvin Fai Hong Lui, Dora Jue Pan, Urs Maurer, Kwong-Wai Choy, Silvia Paracchini, Catherine McBride & Hon-Cheong So. (2024). A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children. npj Science of Learning. https://doi.org/10.1038/s41539-024-00229-7

q2 · i? · associational · r2

Hoeffding's test of independence using full GWAS summary statistics compared all 34 Hong Kong traits against five GenLang reading/language traits; the entry quotes the printed counts "42 achieved nominal signi ficance" and 22 at FDR-adjusted p < 0.1, with the strongest pairs DS_Total, EIS_Total and CVA_Total against GenLang word reading.

"Out of the 170 pairs (34 traits from HK sample x 5 traits from ref. 9) of reading/ language phenotypes, 42 achieved nominal signi ficance (p < 0.05) in the test for genetic dependence, while 22 achieved FDR-adjusted p-values < 0.1 (mostly with'word reading'from the GenLang sample)."

Discussion¶

Learner Variables¶

• Vocabulary — predictor: learners who differ on it differ in outcomes

Related Claims¶

• Top SNPs and genes from prior dyslexia and Chinese reading GWAS show significant overlap with the Hong Kong sample's phenotypes, especially Chinese vocabulary breadth — related
• Polygenic risk scores for educational attainment and cognitive performance show the most consistent associations with language traits, and these associations are stronger for English than Chinese literacy phenotypes — related
• Five independent loci reach genome-wide significance for language/literacy phenotypes including Chinese vocabulary, character and word reading, rapid digit naming, and English lexical decision in Hong Kong Chinese bilingual children — related
• Transcriptome-wide analyses link genetically predicted expression of DUS3L and HSD3B7 to English literacy phenotypes and SEMA6C to Chinese vocabulary breadth — related
• Gene-based tests identify associations including KCNC1 with pure-tone phonological composite, GTF3C1 with Chinese vocabulary measures, and CATSPERD with English word reading — related