Gene-based tests identify associations including KCNC1 with pure-tone phonological composite, GTF3C1 with Chinese vocabulary measures, and CATSPERD with English word reading¶

Claim · All claims
Evidence · 1 study · associational r2 · q2
Currency · newest study 2024 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? MAGMA gene-based tests yielded FDR-corrected significant associations for KCNC1 with PureC_total, GTF3C1 with CVD_Total and CVK_Total, and CATSPERD with EWR_Total and EVB_Total. → Yu-Ping Lin 2024

Evidence¶

Yu-Ping Lin 2024¶

Yu-Ping Lin, Yujia Shi, Ruoyu Zhang, Xiao Xue, Shitao Rao, Liangying Yin, Kelvin Fai Hong Lui, Dora Jue Pan, Urs Maurer, Kwong-Wai Choy, Silvia Paracchini, Catherine McBride & Hon-Cheong So. (2024). A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children. npj Science of Learning. https://doi.org/10.1038/s41539-024-00229-7

q2 · i? · associational · r2

Gene-based aggregation of SNP associations (MAGMA) in the Hong Kong sample produced significant gene-level results; the entry quotes the strongest result, "PureC_total (FDR correctedp = 1.49E-5)" for KCNC1, with GTF3C1 associated with CVD_Total (FDR p = 5.90E-04) and CATSPERD with EWR_Total (FDR p = 2.22E-03). No standardized effect size was printed.

"The most significant association was observed forKCNC1 (potassium voltage-gated channel subfamily C member 1) with PureC_total (FDR correctedp = 1.49E-5). For English-related phenotypes, the most significant association was identi fied for gene CATSPERD"

Discussion¶

Learner Variables¶

• Vocabulary — predictor: learners who differ on it differ in outcomes

Related Claims¶

• Top SNPs and genes from prior dyslexia and Chinese reading GWAS show significant overlap with the Hong Kong sample's phenotypes, especially Chinese vocabulary breadth — related
• Transcriptome-wide analyses link genetically predicted expression of DUS3L and HSD3B7 to English literacy phenotypes and SEMA6C to Chinese vocabulary breadth — related
• Five independent loci reach genome-wide significance for language/literacy phenotypes including Chinese vocabulary, character and word reading, rapid digit naming, and English lexical decision in Hong Kong Chinese bilingual children — a broader claim this one bears on
• Hong Kong sample phenotypes show genetic dependence with GenLang reading traits, with 42 of 170 trait pairs reaching nominal significance and 22 reaching FDR < 0.1, mostly with word reading — related
• The most significant single-variant association is rs6905617 with English Lexical Decision (p = 3.29E-09), located near MANEA and MANEA-AS1 — related
• Polygenic risk scores for educational attainment and cognitive performance show the most consistent associations with language traits, and these associations are stronger for English than Chinese literacy phenotypes — related