The most significant single-variant association is rs6905617 with English Lexical Decision (p = 3.29E-09), located near MANEA and MANEA-AS1¶
Claim · All claims
Evidence · 1 study · associationalr2·q2
Currency · newest study 2024 · not yet checked against its sources · not reviewed by a person
Subclaims¶
Reading the evidence codes
q is the design tier, i the impact, n the sample, and the kind with its r
the rigour judged within that kind: what each code means.
This claim: no standardized effect is recorded in observations/ for it yet, so no benchmark reading is possible.
q2 i? The strongest SNP association in the study was rs6905617 with English Lexical Decision, with the SNP located close to MANEA and MANEA-AS1. → Yu-Ping Lin 2024
Evidence¶
Yu-Ping Lin 2024¶
Yu-Ping Lin, Yujia Shi, Ruoyu Zhang, Xiao Xue, Shitao Rao, Liangying Yin, Kelvin Fai Hong Lui, Dora Jue Pan, Urs Maurer, Kwong-Wai Choy, Silvia Paracchini, Catherine McBride & Hon-Cheong So. (2024). A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children. npj Science of Learning. https://doi.org/10.1038/s41539-024-00229-7
q2 · i? · associational · r2
Single-variant GWAS results in the Hong Kong bilingual-child sample showed the strongest signal for English lexical decision; the entry quotes the printed statistic "p = 3.29E-09" and the SNP's proximity to MANEA and MANEA-AS1. No standardized effect size was printed.
"The most signi ficant association was observed for rs6905617 (p = 3.29E-09) with English Lexical Decision (ELD); the SNP is located close to MANEA (−382.1 kb) and MANEA-AS1 (−364.7 kb)."
Discussion¶
Related Claims¶
- Five independent loci reach genome-wide significance for language/literacy phenotypes including Chinese vocabulary, character and word reading, rapid digit naming, and English lexical decision in Hong Kong Chinese bilingual children — a broader claim this one bears on
- Gene-based tests identify associations including KCNC1 with pure-tone phonological composite, GTF3C1 with Chinese vocabulary measures, and CATSPERD with English word reading — related
- Top SNPs and genes from prior dyslexia and Chinese reading GWAS show significant overlap with the Hong Kong sample's phenotypes, especially Chinese vocabulary breadth — related
- SuSiE fine-mapping of the common-factor locus resolves the signal into a 95% credible set of 22 variants near RHEBL1 — related
Page metadata
| Field | Value |
|---|---|
type |
claim |
id |
rs6905617-english-lexical-decision-manea |
title |
The most significant single-variant association is rs6905617 with English Lexical Decision (p = 3.29E-09), located near MANEA and MANEA-AS1 |
description |
The most significant single-variant association is rs6905617 with English Lexical Decision (p = 3.29E-09), located near MANEA and MANEA-AS1 |
status |
review |
evidence_strength |
moderate |
newest_evidence |
2024 |
generated |
by process:wiki-ingest on 2026-10-26 |
trust |
unverified — no one has confirmed this page's content |
sources |
1 — yu-ping-lin-2024 |
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