Ablating adult hippocampal neurogenesis in naive non-stressed rodents has equivocal effects on baseline anxiety- and depression-like behaviour, specific to ablation model and behavioural test¶
Claim · All claims
Evidence · 1 study · reviewr3·q2
Currency · newest study 2022 · not yet checked against its sources · not reviewed by a person
Subclaims¶
Reading the evidence codes
q is the design tier, i the impact, n the sample, and the kind with its r
the rigour judged within that kind: what each code means.
This claim: no standardized effect is recorded in observations/ for it yet, so no benchmark reading is possible.
q2 i? Most chemical and X-irradiation ablation studies report no baseline anxiety/depression changes, while transgenic ablation models show test- and model-specific anxiety-like effects, including one study reporting reduced anxiety-like behaviour. → Katherine L. Jones 2022
Evidence¶
Katherine L. Jones 2022¶
Katherine L. Jones, Mei Zhou and Dhanisha J. Jhaveri. (2022). Dissecting the role of adult hippocampal neurogenesis towards resilience versus susceptibility to stress-related mood disorders. npj Science of Learning 7:16. https://doi.org/10.1038/s41539-022-00133-y
q2 · i? · review · r3
Narrative review of ablation studies summarised in Table 1 (MAM, X-irradiation, GFAP-TK, Nestin-Bax, Nestin-CreERT2/DTA). The review reports effects emerged "in select behavioural tests and was specific to genetic models used for ablating adult neurogenesis".
"Taken together, the role of adult-born hippocampal neurons in the regulation of baseline anxiety- or depression-related behaviour remains equivocal."
Discussion¶
Related Claims¶
- Whether adult-born hippocampal neurons buffer or exacerbate the behavioural and endocrine effects of chronic stress remains unresolved, with conflicting ablation findings — related
- Chronic, but not acute, administration of clinical antidepressants enhances adult hippocampal neurogenesis across multiple stages of the neurogenic process — related
- Genetic or chemogenetic enhancement of adult hippocampal neurogenesis does not improve baseline mood but can promote behavioural resilience to chronic stressors — related
- Ablation of adult hippocampal neurogenesis blocks the anxiolytic effects of some antidepressants, indicating adult-born neurons are required for some antidepressant efficacy — related
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by process:wiki-ingest on 2026-10-26 |
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