Ablation of adult hippocampal neurogenesis blocks the anxiolytic effects of some antidepressants, indicating adult-born neurons are required for some antidepressant efficacy¶
Claim · All claims
Evidence · 1 study · reviewr2·q2
Currency · newest study 2022 · not yet checked against its sources · not reviewed by a person · recheck by 2027: baselines and conditions change
Subclaims¶
Reading the evidence codes
q is the design tier, i the impact, n the sample, and the kind with its r
the rigour judged within that kind: what each code means.
This claim: no standardized effect is recorded in observations/ for it yet, so no benchmark reading is possible.
q2 i? X-irradiation ablation blocked the anxiolytic effects of fluoxetine and imipramine on the novelty-suppressed feeding test, a finding replicated across ablation approaches and extended by chemogenetic silencing. → Katherine L. Jones 2022
Evidence¶
Katherine L. Jones 2022¶
Katherine L. Jones, Mei Zhou and Dhanisha J. Jhaveri. (2022). Dissecting the role of adult hippocampal neurogenesis towards resilience versus susceptibility to stress-related mood disorders. npj Science of Learning 7:16. https://doi.org/10.1038/s41539-022-00133-y
q2 · i? · review · r2
Narrative review of loss-of-function studies testing whether neurogenesis is required for antidepressant efficacy; findings described as "more consistent" than baseline-ablation studies, with replication by other ablation studies and by Gi-DREADD silencing blocking fluoxetine efficacy.
"Using head-focused X-rays, Hen and colleagues were the first to show that the ablation of adult hippocampal neurogenesis blocked some of the bene ficial effects of antidepressants fluoxetine and imipramine"
Discussion¶
Related Claims¶
- Chronic, but not acute, administration of clinical antidepressants enhances adult hippocampal neurogenesis across multiple stages of the neurogenic process — related
- Ablating adult hippocampal neurogenesis in naive non-stressed rodents has equivocal effects on baseline anxiety- and depression-like behaviour, specific to ablation model and behavioural test — related
- Genetic or chemogenetic enhancement of adult hippocampal neurogenesis does not improve baseline mood but can promote behavioural resilience to chronic stressors — related
- Whether adult-born hippocampal neurons buffer or exacerbate the behavioural and endocrine effects of chronic stress remains unresolved, with conflicting ablation findings
Page metadata
| Field | Value |
|---|---|
status |
review |
generated |
by process:wiki-ingest on 2026-10-26 |
trust |
unverified — no one has confirmed this page's content |
Frontmatter is the page's machine-readable record — see the Schema & Guide.