SuSiE fine-mapping of the common-factor locus resolves the signal into a 95% credible set of 22 variants near RHEBL1¶

Claim · All claims
Evidence · 1 study · associational r2 · q2
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? Fine-mapping within ±100 kb of rs7969091 yields a single 95% credible set of 22 variants with no single variant reaching PIP > 0.5. → Shiying Wang 2026

Evidence¶

Shiying Wang 2026¶

Shiying Wang, Joan Bosson-Heenan, Andrew Grotzinger, Jan C. Frijters & Jeffrey R. Gruen. (2026). Shared genetic architecture of reading and attention disorders using genomic structural equation modeling. npj Science of Learning. https://doi.org/10.1038/s41539-026-00433-7

q2 · i? · associational · r2

SuSiE Bayesian fine-mapping of the 12q13.12 locus using European 1000 Genomes LD, covering 194 SNPs within ±100 kb. The article reports "a single 95% credible set containing 22 variants" and that no single variant reached PIP > 0.5, reflecting dense LD.

"The association signal was resolved into a single 95% credible set containing 22 variants (Table 2). All of them had suggestive p-values (𝑝 < 1 × 10−5) in the GWAS predicated on Cg. The credible set achieved 95% cumulative posterior probability, indicating a high likelihood that it contains the causal variants."

Discussion¶

Related Claims¶

• Stratified Genomic SEM finds the common factor enriched only in primate-conserved genomic regions — related
• A multivariate GWAS on the common factor identifies a genome-wide significant locus on chromosome 12q13.12 that no univariate trait GWAS detected — a broader claim this one bears on
• Transcriptome-wide SEM links the common factor to tissue-specific expression of RHEBL1 and LMBR1L within the same 12q13.12 locus — related
• The most significant single-variant association is rs6905617 with English Lexical Decision (p = 3.29E-09), located near MANEA and MANEA-AS1 — related