rTMS of right IFJ causally reduces top-down modulation during encoding and working memory accuracy¶
Claim · All claims
Evidence · 1 study · reviewr2·q2
Currency · newest study 2012 · checked against its sources 2026-10-20 (automated, 1 of 1 entry) · not reviewed by a person
Subclaims¶
Reading the evidence codes
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q2 i? In a study summarised by the review (Zanto et al., 2011), ten minutes of rTMS to right IFJ significantly diminished top-down modulation of the P1 ERP component and significantly reduced color working memory accuracy, with recovery of both over time. → Gazzaley A 2012
Evidence¶
Gazzaley A 2012¶
Gazzaley A, Nobre AC. (2012). Top-down modulation: Bridging selective attention and working memory. Trends in Cognitive Sciences. https://doi.org/10.1016/j.tics.2011.11.014
q2 · i? · review · r2
Narrative review that summarises a separate causal perturbation study (Zanto et al., 2011) combining fMRI-guided rTMS of right IFJ with EEG during a feature delayed-response task. The review reports the significant P1 modulation reduction and "a significant reduction in WM accuracy for color", with P1 modulation and WM performance recovering together after rTMS.
"Ten minutes of rTMS to the right IFJ resulted in significantly diminished top-down modulation of the P1 component of the ERP to color stimuli at posterior electrodes"
Discussion¶
Related Claims¶
- Age-related deficits in top-down modulation underlie much of older adults' working memory impairment — related
- Selective attention facilitates working memory retrieval, and selecting from WM resembles visual search — related
- Early (within ~100 ms) attentional modulation during encoding predicts subsequent working memory accuracy — related
- Retro-cues during maintenance dynamically modulate working memory representations and confer large performance benefits — related
- Predictive cues aid transfer of perceptual representations into working memory via pre-encoding top-down modulation — related
- Distraction during maintenance impairs working memory, with distractor processing inversely related to recognition accuracy — related
- Post-hoc finding: P1 latency was increased for attended versus unattended unilateral stimuli, selectively over the ipsilateral ROI — related
- Perceptual attention and working memory are distinct entities that causally affect each other — related
- Perceptual attention is probably necessary but not sufficient for encoding stimuli into working memory — related
Page metadata
| Field | Value |
|---|---|
type |
claim |
id |
rtms-ifj-causal-top-down-modulation-wm |
title |
rTMS of right IFJ causally reduces top-down modulation during encoding and working memory accuracy |
description |
rTMS of right IFJ causally reduces top-down modulation during encoding and working memory accuracy |
status |
review |
evidence_strength |
moderate |
newest_evidence |
2012 |
source_checked |
2026-10-20 |
generated |
by process:wiki-ingest on 2026-10-17 |
trust |
unverified — no one has confirmed this page's content |
sources |
1 — gazzaley-a-2012 |
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