Transcriptome-wide SEM links the common factor to tissue-specific expression of RHEBL1 and LMBR1L within the same 12q13.12 locus¶

Claim · All claims
Evidence · 1 study · associational r2 · q2
Currency · newest study 2026 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? T-SEM across genes and 13 brain tissues identifies five significant associations involving two unique genes, RHEBL1 and LMBR1L, both located within the GWAS locus. → Shiying Wang 2026

Evidence¶

Shiying Wang 2026¶

Shiying Wang, Joan Bosson-Heenan, Andrew Grotzinger, Jan C. Frijters & Jeffrey R. Gruen. (2026). Shared genetic architecture of reading and attention disorders using genomic structural equation modeling. npj Science of Learning. https://doi.org/10.1038/s41539-026-00433-7

q2 · i? · associational · r2

T-SEM analysis using FUSION weights from 13 GTEx v8 brain tissues across 51,223 tissue-specific gene expression estimates. The article reports associations at "a Bonferroni-corrected threshold of p < 9.76 × 10⁻⁷" involving RHEBL1 and LMBR1L, both within the GWAS locus. No effect size is printed.

"T-SEM identified five significant associations (Table 3) at a Bonferroni-corrected threshold of p < 9.76 × 10⁻⁷. These associations involved two unique genes: RHEBL1 and LMBR1L (MIM: 610007). Both genes are within the locus 12q13.12 identified in the GWAS predicated on Cg (Figure 3B), consistent with the GWAS results."

Discussion¶

Related Claims¶

• Stratified Genomic SEM finds the common factor enriched only in primate-conserved genomic regions — related
• A multivariate GWAS on the common factor identifies a genome-wide significant locus on chromosome 12q13.12 that no univariate trait GWAS detected — a broader claim this one bears on
• SuSiE fine-mapping of the common-factor locus resolves the signal into a 95% credible set of 22 variants near RHEBL1 — related