Transcriptome-wide analyses link genetically predicted expression of DUS3L and HSD3B7 to English literacy phenotypes and SEMA6C to Chinese vocabulary breadth¶

Claim · All claims
Evidence · 1 study · associational r2 · q2
Currency · newest study 2024 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q2 i? S-PrediXcan showed DUS3L significantly associated (FDR < 0.05) with EWR_Total in four brain regions, and S-MultiXcan identified HSD3B7 with EVA_total (FDR p = 9.55E-20) and SEMA6C with CVB_Total (FDR p = 2.77E-12). → Yu-Ping Lin 2024

Evidence¶

Yu-Ping Lin 2024¶

Yu-Ping Lin, Yujia Shi, Ruoyu Zhang, Xiao Xue, Shitao Rao, Liangying Yin, Kelvin Fai Hong Lui, Dora Jue Pan, Urs Maurer, Kwong-Wai Choy, Silvia Paracchini, Catherine McBride & Hon-Cheong So. (2024). A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children. npj Science of Learning. https://doi.org/10.1038/s41539-024-00229-7

q2 · i? · associational · r2

Transcriptome-wide association analyses (S-PrediXcan/S-MultiXcan using GTEx v7 elastic-net weights) linked genetically regulated expression to phenotypes; the entry quotes the DUS3L result across four brain regions, with HSD3B7-EVA_total (FDR p = 9.55E-20) the most significant S-MultiXcan association and SEMA6C-CVB_Total (FDR p = 2.77E-12) the strongest for Chinese literacy. No standardized effect size was printed.

"The most significant associations were observed for DUS3L, which showed significant associations (FDR < 0.05) with EWR_Total in four brain regions including amygdala, caudate basal, cerebellar hemisphere and putamen"

Discussion¶

Learner Variables¶

• Communication Skills — predictor: learners who differ on it differ in outcomes
• Vocabulary — predictor: learners who differ on it differ in outcomes

Related Claims¶

• Gene-based tests identify associations including KCNC1 with pure-tone phonological composite, GTF3C1 with Chinese vocabulary measures, and CATSPERD with English word reading — related
• Hong Kong sample phenotypes show genetic dependence with GenLang reading traits, with 42 of 170 trait pairs reaching nominal significance and 22 reaching FDR < 0.1, mostly with word reading — related
• Five independent loci reach genome-wide significance for language/literacy phenotypes including Chinese vocabulary, character and word reading, rapid digit naming, and English lexical decision in Hong Kong Chinese bilingual children — related
• Polygenic risk scores for educational attainment and cognitive performance show the most consistent associations with language traits, and these associations are stronger for English than Chinese literacy phenotypes — related