APOE genotype does not modify the association between Mediterranean diet or fish intake and cognitive function¶

Claim · All claims
Evidence · 1 study (2 entries) · associational r2–r3 · q3
Currency · newest study 2020 · not yet checked against its sources · not reviewed by a person

Subclaims¶

q3 i? No significant interactions were observed between aMED and APOE haplotype for cognitive impairment or rate of decline in either cohort. → Keenan Tiarnán D. 2020 q3 i? No significant interactions were observed between fish intake and APOE haplotype for cognitive impairment. → Keenan Tiarnán D. 2020 (2)

Evidence¶

Keenan Tiarnán D. 2020¶

Keenan Tiarnán D., Agrón Elvira, Mares Julie A., Clemons Traci E., van Asten Freekje, Swaroop Anand, Chew Emily Y.; AREDS and AREDS2 Research Groups. (2020). Adherence to a Mediterranean diet and cognitive function in the Age-Related Eye Disease Studies 1 & 2. Alzheimer's & Dementia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328271/

q3 · i? · associational · r3

Genotype interaction analysis in AREDS2 longitudinal models testing aMED by APOE haplotype for rate of cognitive decline. The article reports "no significant interactions were observed between aMED and APOE haplotype, in terms of rate of decline".

"However, no significant interactions were observed between aMED and APOE haplotype, in terms of rate of decline (P-value for interaction = 0.80 for TICS-M and P-value for interaction = 0.51 for the composite)."

Keenan Tiarnán D. 2020 (2)¶

Keenan Tiarnán D., Agrón Elvira, Mares Julie A., Clemons Traci E., van Asten Freekje, Swaroop Anand, Chew Emily Y.; AREDS and AREDS2 Research Groups. (2020). Adherence to a Mediterranean diet and cognitive function in the Age-Related Eye Disease Studies 1 & 2. Alzheimer's & Dementia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328271/

q3 · i? · associational · r2

Cross-sectional interaction analysis in both AREDS and AREDS2 testing fish intake by APOE haplotype for cognitive impairment. The article reports "no significant interactions were observed".

"In analyses of interactions between fish intake and APOE haplotype, for the outcome of cognitive impairment, no significant interactions were observed."

Discussion¶

Related Claims¶

• Individual aMED components: vegetable, nut, and moderate alcohol intakes show protective associations with cognitive function — related
• Higher fish intake is associated with lower risk of cognitive impairment in older adults — related
• Higher fish intake is associated with slower cognitive decline over 5 to 10 years in AREDS2 — related
• Higher Mediterranean diet adherence is not associated with slower cognitive decline over 5 to 10 years — related
• Higher Mediterranean diet adherence is associated with lower risk of cognitive impairment in older adults without dementia — related
• The aMED–cognition associations persist after adjustment for education level — related
• Higher Mediterranean diet adherence is associated with higher cognitive test scores, with dose-response associations — related