Higher Mediterranean diet adherence is associated with lower risk of cognitive impairment in older adults without dementia¶

Claim · All claims
Evidence · 1 study (2 entries) · associational r3 · q3 · i2 medium
Currency · newest study 2020 · not yet checked against its sources · not reviewed by a person · overdue for a recheck since 2025: baselines and conditions change

Subclaims¶

q3 i2 In AREDS, participants in the highest aMED tertile had lower odds of cognitive impairment (3MS <80) than those in the lowest tertile (OR = 0.36, P = .0001). → Keenan Tiarnán D. 2020 q3 i2 In AREDS2, participants in the highest aMED tertile had lower odds of cognitive impairment (TICS-M <30) than those in the lowest tertile (OR = 0.56, P < .0001). → Keenan Tiarnán D. 2020 (2)

Evidence¶

Keenan Tiarnán D. 2020¶

Keenan Tiarnán D., Agrón Elvira, Mares Julie A., Clemons Traci E., van Asten Freekje, Swaroop Anand, Chew Emily Y.; AREDS and AREDS2 Research Groups. (2020). Adherence to a Mediterranean diet and cognitive function in the Age-Related Eye Disease Studies 1 & 2. Alzheimer's & Dementia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328271/

q3 · i2 · associational · r3

Cross-sectional logistic regression in the AREDS ancillary cognitive study (3,029 participants analyzed), comparing aMED tertile 3 with tertile 1. The article reports an odds ratio of OR = 0.36 (P = .0001; 3MS) and OR = 0.56 (P = .001; composite) for cognitive impairment.

"In AREDS, the odds ratios for cognitive impairment, in aMED tertile 3 (vs 1), were 0.36 (P = .0001; 3MS) Figure 1A and 0.56 (P = .001; composite) Figure 1A."

Keenan Tiarnán D. 2020 (2)¶

Keenan Tiarnán D., Agrón Elvira, Mares Julie A., Clemons Traci E., van Asten Freekje, Swaroop Anand, Chew Emily Y.; AREDS and AREDS2 Research Groups. (2020). Adherence to a Mediterranean diet and cognitive function in the Age-Related Eye Disease Studies 1 & 2. Alzheimer's & Dementia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328271/

q3 · i2 · associational · r3

Cross-sectional analysis in AREDS2 (3,326 participants analyzed) using telephone-administered TICS-M and composite scores, comparing aMED tertile 3 with tertile 1. The article reports OR = 0.56 (P < .0001; TICS-M) and OR = 0.48 (P < .0001; composite).

"In AREDS2, the equivalent odds ratios were 0.56 (P < .0001; TICS-M) and 0.48 (P < .0001; composite) Figure 1C and equivalent linear regression estimates were +1.0 (P < .0001) and +1.5 (P < .0001) Figure 1D, respectively."

Discussion¶

Related Claims¶

• The aMED–cognition associations persist after adjustment for education level — related
• APOE genotype does not modify the association between Mediterranean diet or fish intake and cognitive function — related
• Higher fish intake is associated with lower risk of cognitive impairment in older adults — related
• Higher Mediterranean diet adherence is associated with higher cognitive test scores, with dose-response associations — related
• Higher Mediterranean diet adherence is not associated with slower cognitive decline over 5 to 10 years — related
• Individual aMED components: vegetable, nut, and moderate alcohol intakes show protective associations with cognitive function — related
• Mediterranean Diet adherence alone shows no significant association with self-regulation, but helps in combination with other habits — related
• Higher fish intake is associated with slower cognitive decline over 5 to 10 years in AREDS2 — related